Protein Info for Atu4711 in Agrobacterium fabrum C58

Annotation: two component sensor kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 452 transmembrane" amino acids 16 to 43 (28 residues), see Phobius details amino acids 171 to 194 (24 residues), see Phobius details PF02518: HATPase_c" amino acids 349 to 450 (102 residues), 70.7 bits, see alignment E=7.1e-24

Best Hits

KEGG orthology group: None (inferred from 100% identity to atu:Atu4711)

Predicted SEED Role

"Sensor protein PhoQ (EC 2.7.13.3)" in subsystem Lipid A modifications (EC 2.7.13.3)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7CVN5 at UniProt or InterPro

Protein Sequence (452 amino acids)

>Atu4711 two component sensor kinase (Agrobacterium fabrum C58)
MSEPKINHGPSISRRLTVFSVIFVTASVMIASIILYLIVAGVVREQIDQRLDTQIEGLRS
ALSIDEAGRVTLNAALDGPPFDRRGSGWYWQIRGEGVAITSRSLAGQSLDNPPSPFNWGK
MMEHGPRPGVNAELHGQDLYLRSIQTMVGAKLIEITATAPRFALVAPARSALLWLIPAMT
LLGASLVAGIFLQVRYGLRPLRQLTADISSISAGTLERLPDADVQELRPASREINRLVEQ
NSERLTETRLHFANLAHGLKTPVTSLYLALNDTNDPDNTMRALVDRIDQRIRHHLARARK
TAAGGVAATTPVRPRVDDILEIMTHIYADRGVVATVEVDDTLRVQVGPEDLDEIIGNITD
NAFKWAKGRVRISARQTGRDILLTISDDGPGIDNALVSEVFEPGRRMDETVPGDGFGLTI
VKELVELHGGRISMERNGDGGLTCLLTLPSAI