Protein Info for Atu4692 in Agrobacterium fabrum C58

Annotation: diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 724 TIGR00229: PAS domain S-box protein" amino acids 26 to 149 (124 residues), 42.1 bits, see alignment E=8.7e-15 PF00989: PAS" amino acids 28 to 140 (113 residues), 26.8 bits, see alignment E=9e-10 PF08448: PAS_4" amino acids 34 to 144 (111 residues), 53 bits, see alignment E=7.8e-18 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 288 to 447 (160 residues), 145.2 bits, see alignment E=1.6e-46 PF00990: GGDEF" amino acids 290 to 444 (155 residues), 152.8 bits, see alignment E=1.4e-48 PF00563: EAL" amino acids 465 to 699 (235 residues), 233.6 bits, see alignment E=4.2e-73

Best Hits

KEGG orthology group: None (inferred from 100% identity to atu:Atu4692)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7CVL6 at UniProt or InterPro

Protein Sequence (724 amino acids)

>Atu4692 diguanylate cyclase (Agrobacterium fabrum C58)
MSRKKRDITPSASPAMGENANPSGRHTLLEAMIDHVPDFIYAKDLEGRFLFANRAIVNEN
GFESVEELIGLTDYDIHGEAARHAGIPDTEARVMRTGEPDLGYEERAMRGDVDRWLMMSR
VPLKDKSGEIIGVVGASRDITQKKASERLLQAQAHILEMIVAAARIEDFLEEFVKAIENL
ATGLACAVRVFEAAVGEPSVYVSPALAQQAGLTALISNVSDPESLAHSGEDTAFSFDIPA
SEGKAHGFVWCRLAGRKPDEALVEFIGAAARMAGLAIDRKRAAEHIAFLADHDMLTRLPN
RRFLDTRLPEILAAAAKANRRVGIGFLDLDNFKQINDTLGHSIGDALLSKTAERIAASLG
QNDLVLRVGGDEFVIILEEHKDDVEKHLQRIRAAVSQPLRIRNYDIKVTCSIGMAFFPEH
GKTTAEIVAAADLAMYEVKHNGRDSIATFTPNMADDLRKKFTRIEEMRKAVERDEFVLHF
QPQVDLANGRISGVEALVRWQHPTEGLLGPVEFIGLAEETGLIVELGANILKKACRQAQA
WVAAGLSPVKMAVNISPRQFQGGLVQQIRSVLKETGLAPSLLEIEITETLIIQDVETSVR
IMHAIKQMGVSLALDDFGIGYSCLGMLKTFPLSCMKIDRSFLTHLPEKTKDSAIVTIMIQ
LAGSLGIDVIAEGVETAEQANFLRTAGCPYGQGYYFSRPLPADAIEATLANRTIFPTGLS
GGRS