Protein Info for Atu4628 in Agrobacterium fabrum C58

Annotation: diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 779 transmembrane" amino acids 15 to 36 (22 residues), see Phobius details amino acids 48 to 72 (25 residues), see Phobius details amino acids 78 to 100 (23 residues), see Phobius details amino acids 107 to 130 (24 residues), see Phobius details amino acids 142 to 163 (22 residues), see Phobius details amino acids 173 to 193 (21 residues), see Phobius details amino acids 213 to 236 (24 residues), see Phobius details PF03707: MHYT" amino acids 58 to 103 (46 residues), 42.5 bits, see alignment 7.7e-15 amino acids 119 to 173 (55 residues), 31.3 bits, see alignment 2.4e-11 TIGR00229: PAS domain S-box protein" amino acids 255 to 349 (95 residues), 26.5 bits, see alignment E=6e-10 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 351 to 510 (160 residues), 142.5 bits, see alignment E=1e-45 PF00990: GGDEF" amino acids 354 to 508 (155 residues), 152.3 bits, see alignment E=1.5e-48 PF00563: EAL" amino acids 531 to 761 (231 residues), 242.7 bits, see alignment E=5.5e-76

Best Hits

KEGG orthology group: None (inferred from 100% identity to atu:Atu4628)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7CVF8 at UniProt or InterPro

Protein Sequence (779 amino acids)

>Atu4628 diguanylate cyclase (Agrobacterium fabrum C58)
MFTVLECVAIQHDHAVVLLAAVICLLGMFAFFHLLLRADESPAGRKPYWVLVAAFAAGLS
VWATHFVAMLAYRGAVPIGYDFFFTALSAALAVFGFWLALVARSQAIYSSLIVGTLVTLS
VAVMHFVGMAGMDVAATISYRWGPVFGGSAVSWAAFVLAFFLFRRLASWKRIAAPAGAAI
FGICALHFTAMSATVLTPDPSMSGPDPDNVGRLIMIGAISGVTFLILFATAVAALVDRYL
VDLKGLVDATLDGLAVVRDGRIVELNTRFAGLLGREEASLVGRNPDDLFKAVDGQPTYLS
RPAPVEAIRERGGQAQVFELGVRTIEYRGRPCEVMAIRDLTEKREAQREIEYLARHDVLT
GLSNRTMFQTRLHQQIDNGDEEDEFALLALDLDRFKAVNDIFGHAEGDRVLKKVAAILDE
CARAGDVVARLGGDEFVILTARHTKADEARLLAETILGMFALKMNVVNDPTAVGVSIGIA
VFPRDGQDHESIMHAADLALYRAKMGGRGILAFYDPLMDQEARERRQLETDLRLAINRDE
LVLNYQPVLSVECGQVVGYEALVRWQHPTRGVVPPDVFIPIAEESGIIISLGEWVLREAC
RQASTWAPHLKIAVNVSPLQFSLANLGHVVCTVLMQTGLSPNRLELEITEAALLKDRKAT
LVILNQLKALGVAIVMDDFGTGYSSLSNLQSFPFDKIKIDRSFIAAMSEDDNARAIVRAV
IGLGRSLDLPVTAEGIETDAQYRMVVDEGCAQAQGYLFGRPDVAPAPAASTAKRKKHSV