Protein Info for Atu4546 in Agrobacterium fabrum C58

Annotation: IclR family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 253 TIGR02431: beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family" amino acids 5 to 252 (248 residues), 344.8 bits, see alignment E=1.3e-107 PF09339: HTH_IclR" amino acids 12 to 62 (51 residues), 53.2 bits, see alignment 2e-18 PF01614: IclR_C" amino acids 79 to 247 (169 residues), 123.3 bits, see alignment E=8.1e-40

Best Hits

Swiss-Prot: 44% identical to PCAR_PSEPU: Pca regulon regulatory protein (pcaR) from Pseudomonas putida

KEGG orthology group: K02624, IclR family transcriptional regulator, pca regulon regulatory protein (inferred from 100% identity to atu:Atu4546)

Predicted SEED Role

"Pca regulon regulatory protein PcaR" in subsystem Protocatechuate branch of beta-ketoadipate pathway

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7CV82 at UniProt or InterPro

Protein Sequence (253 amino acids)

>Atu4546 IclR family transcriptional regulator (Agrobacterium fabrum C58)
MAVSERDMMGGLAKGLRVIEAFSAERPRLSISDAAEIAGLDRATTRRCLLTLSELGYAAY
DGKFFTVTPKVLRLGTGCLATMPLPKIVQPLLDRLSEEIGQSTSVSILDEAEIVYVARAA
QQRVMSIALMPGSRLPAYCTSMGRVLLAAQPAERRRDILEASRLVARTEKTITDMDALLA
EIEVTGHRGYALIDQEVEIGLRSIAVPLKTVRGQTVAALNVGLAASVASMEELVERYLPA
LLAVQRELARMLV