Protein Info for Atu4177 in Agrobacterium fabrum C58

Annotation: ATP-dependent Clp protease, ATP-binding subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 874 TIGR03346: ATP-dependent chaperone protein ClpB" amino acids 7 to 857 (851 residues), 1402.4 bits, see alignment E=0 PF02861: Clp_N" amino acids 17 to 67 (51 residues), 48.2 bits, see alignment 5.7e-16 amino acids 94 to 145 (52 residues), 38.4 bits, see alignment 6.8e-13 PF00004: AAA" amino acids 204 to 317 (114 residues), 45 bits, see alignment E=9e-15 amino acids 604 to 722 (119 residues), 31.7 bits, see alignment E=1.1e-10 PF17871: AAA_lid_9" amino acids 344 to 445 (102 residues), 127.8 bits, see alignment E=9e-41 PF07724: AAA_2" amino acids 598 to 762 (165 residues), 238.8 bits, see alignment E=1.9e-74 PF07728: AAA_5" amino acids 603 to 723 (121 residues), 52.1 bits, see alignment E=4.3e-17 PF10431: ClpB_D2-small" amino acids 768 to 848 (81 residues), 101.1 bits, see alignment E=1.7e-32

Best Hits

Swiss-Prot: 100% identical to CLPB_AGRFC: Chaperone protein ClpB (clpB) from Agrobacterium fabrum (strain C58 / ATCC 33970)

KEGG orthology group: K03695, ATP-dependent Clp protease ATP-binding subunit ClpB (inferred from 100% identity to atu:Atu4177)

Predicted SEED Role

"ClpB protein" in subsystem Protein chaperones or Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7CU92 at UniProt or InterPro

Protein Sequence (874 amino acids)

>Atu4177 ATP-dependent Clp protease, ATP-binding subunit (Agrobacterium fabrum C58)
MNIDKYSERVRGFLQSAQTFALAENHQQFSPEHVLKVLLDDEQGMAASLIERAGGDAKEA
RLANDAALAKLPKVSGGNGGLSLTAPLAKVFSTAEDLAKKAGDSFVTVERLLQALAIESS
ASTSASLKKAGATAQALNQVINDIRKGRTADSANAEQGFDALKKYARDLTEEAREGRLDP
VIGRDDEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIAEGLALRIVNGDVPESLKDKKLMA
LDMGALIAGAKYRGEFEERLKAVLNEVQAENGGIILFIDEMHTLVGAGKADGAMDASNLL
KPALARGELHCVGATTLDEYRKHVEKDPALARRFQPVLVDEPNVEDTISILRGLKEKYEQ
HHKVRISDSALVAAATLSNRYITDRFLPDKAIDLMDEAASRLRMQVDSKPEELDELDRRI
IQLKIEREALKQETDQSSVDRLRKLEDELADTEEKADALTARWQAEKQKLGHAADLKKRL
DEARNELAIAQRNGQFQRAGELTYGIIPGLEKELAAAEARDSSGAGSMVQEVVTPDNIAH
VVSRWTGIPVDKMLEGQREKLLRMEDELAKSVVGQGEAVQAVSKAVRRSRAGLQDPNRPI
GSFIFLGPTGVGKTELTKSLARFLFDDETAMVRLDMSEYMEKHSVARLIGAPPGYVGYEE
GGALTEAVRRRPYQVVLFDEIEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTIIIMTS
NLGSEFMTQMGDNDDVDSVRELVMERVRSHFRPEFLNRIDDIILFHRLRRDEMGAIVEIQ
LKRLVSLLADRKITLELDEDARSWLANKGYDPAYGARPLKRVIQKSVQDRLAEMILGGEI
PDGSRVKVTSGTDRLLFKVKPAKGEAETETADAA