Protein Info for Atu4149 in Agrobacterium fabrum C58
Annotation: UDP-glucose 6-dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 81% identical to UDG_RHIME: UDP-glucose 6-dehydrogenase (rkpK) from Rhizobium meliloti (strain 1021)
KEGG orthology group: K00012, UDPglucose 6-dehydrogenase [EC: 1.1.1.22] (inferred from 100% identity to atu:Atu4149)MetaCyc: 47% identical to UDP-glucose 6-dehydrogenase (Bacillus subtilis subtilis 168)
UDP-glucose 6-dehydrogenase. [EC: 1.1.1.22]
Predicted SEED Role
"UDP-glucose 6-dehydrogenase (EC 1.1.1.22)" (EC 1.1.1.22)
MetaCyc Pathways
- colanic acid building blocks biosynthesis (11/11 steps found)
- superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (5/6 steps found)
- UDP-α-D-xylose biosynthesis (2/2 steps found)
- UDP-α-D-glucuronate biosynthesis (from UDP-glucose) (1/1 steps found)
- UDP-sugars interconversion (4/9 steps found)
- teichuronic acid biosynthesis (B. subtilis 168) (2/9 steps found)
KEGG Metabolic Maps
- Ascorbate and aldarate metabolism
- Nucleotide sugars metabolism
- Pentose and glucuronate interconversions
- Starch and sucrose metabolism
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.1.1.22
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A9CG56 at UniProt or InterPro
Protein Sequence (443 amino acids)
>Atu4149 UDP-glucose 6-dehydrogenase (Agrobacterium fabrum C58) MRIVMIGSGYVGLVSGACFADFGHDVVCVDKMPEKIEALKSGHIPIFEPGLETIVANNAK AGRLSFTTDLSAAVANADVVFIAVGTPSRRGDGHADLGYVYAAAKEIAHALDGFTVIVTK STVPVGTGDEVERIIREENPSADFAVVSNPEFLREGAAIEDFKRPDRIVVGLSDERARPV MTEVYRPLYLNQSPLLFTTRRASELIKYAANAFLAMKITFINEMADLCEKVGANVQDVSR GIGLDGRIGSKFLHAGPGYGGSCFPKDTLALAKTAQDYDAPVRLIETTIAVNDTRKRAMG RKVINAVGGDVRGKKIAVLGLTFKPNTDDMRDSPAIAIIQTLQDGGAKVVGYDPEGMANA RHLMEDIDYAAGPYEAAEGADAVVIVTEWNQFRALDLPRLKAIMKSPVLVDLRNIYRTDE VAGHGFIYAAVGRPHEGSSGNDT