Protein Info for Atu4110 in Agrobacterium fabrum C58

Annotation: serine dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 249 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details PF08659: KR" amino acids 3 to 178 (176 residues), 51.9 bits, see alignment E=1.9e-17 PF00106: adh_short" amino acids 4 to 186 (183 residues), 179.3 bits, see alignment E=1.2e-56 PF01370: Epimerase" amino acids 5 to 137 (133 residues), 31 bits, see alignment E=3.6e-11 PF13561: adh_short_C2" amino acids 9 to 222 (214 residues), 128.5 bits, see alignment E=6.6e-41

Best Hits

Swiss-Prot: 100% identical to SDH_AGRFC: Serine 3-dehydrogenase (sdh) from Agrobacterium fabrum (strain C58 / ATCC 33970)

KEGG orthology group: K05886, serine 3-dehydrogenase [EC: 1.1.1.276] (inferred from 100% identity to atu:Atu4110)

MetaCyc: 53% identical to sulfoacetaldehyde reductase monomer (Chromohalobacter salexigens DSM 3043)
RXN-12148 [EC: 1.1.1.313]

Predicted SEED Role

"Oxidoreductase"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.276 or 1.1.1.313

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8U8I2 at UniProt or InterPro

Protein Sequence (249 amino acids)

>Atu4110 serine dehydrogenase (Agrobacterium fabrum C58)
MSGTILITGATSGFGQATARRFVKEGWKVIGTGRRAERLEALAAELGQAFHGIAFDITDE
DATEKALAALPDGFRDIDILVNNAGLALGTAPAPQVALKDWQTMVDTNITGLLNITHHLL
PTLIKQKGIVVNLSSVAAHYPYLGGNVYGGTKAFLRQFSLGLRSDLHGKGVRVTSIEPGM
CETEFTLVRTGGNQEASDNLYKGVNPITADDIANTIYWVASQPKHININSLELMPVNQSF
AGFQVYRES