Protein Info for Atu3934 in Agrobacterium fabrum C58

Annotation: imidazolonepropionase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 419 TIGR01224: imidazolonepropionase" amino acids 38 to 415 (378 residues), 462.1 bits, see alignment E=6.1e-143 PF01979: Amidohydro_1" amino acids 75 to 394 (320 residues), 73.9 bits, see alignment E=1.5e-24 PF07969: Amidohydro_3" amino acids 142 to 393 (252 residues), 67.1 bits, see alignment E=2.3e-22

Best Hits

Swiss-Prot: 100% identical to HUTI_AGRFC: Imidazolonepropionase (hutI) from Agrobacterium fabrum (strain C58 / ATCC 33970)

KEGG orthology group: K01468, imidazolonepropionase [EC: 3.5.2.7] (inferred from 100% identity to atu:Atu3934)

MetaCyc: 58% identical to imidazolonepropionase (Pseudomonas fluorescens)
Imidazolonepropionase. [EC: 3.5.2.7]

Predicted SEED Role

"Imidazolonepropionase (EC 3.5.2.7)" in subsystem Histidine Degradation (EC 3.5.2.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.2.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8U8Z6 at UniProt or InterPro

Protein Sequence (419 amino acids)

>Atu3934 imidazolonepropionase (Agrobacterium fabrum C58)
MPGNNSAKGTATGNATALWRNAQLATLNPAMDGIGAVENAVIAVRNGRIAFAGPESDLPD
DLSTADETTDCGGRWITPALIDCHTHLVFGGNRAMEFEMRLNGATYEEIAKAGGGIVSSV
RDTRALSDEVLVAQALPRLDTLLSEGVSTIEIKSGYGLDIETELKMLRVARRLETLRPVR
IVTSYLAAHATPADYKGRNADYITDVVLPGLEKAHAEGLADAVDGFCEGIAFSVKEIDRV
FAAAQQRGLPVKLHAEQLSNLGGAELAASYNALSADHLEYLDETGAKALAKAGTVAVLLP
GAFYALREKQLPPVQALRDAGAEIALATDCNPGTSPLTSLLLTMNMGATLFRMTVEECLT
ATTRNAAKALGLLAETGTLEAGKSADFAIWDIERPAELVYRIGFNPLHARIFKGQKVSP