Protein Info for Atu3871 in Agrobacterium fabrum C58

Annotation: L-lactate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01070: FMN_dh
  • amino acids 16 to 378 (363 residues), 433.5 bits, E=3e-134

Best Hits

KEGG orthology group: K00101, L-lactate dehydrogenase (cytochrome) [EC: 1.1.2.3] (inferred from 100% identity to atu:Atu3871)

Predicted SEED Role

"L-lactate dehydrogenase (EC 1.1.2.3)" in subsystem L-rhamnose utilization or Lactate utilization or Respiratory dehydrogenases 1 (EC 1.1.2.3)

MetaCyc Pathways

• methylglyoxal degradation V (2/3 steps found)
• lactate fermentation to acetate, CO₂ and hydrogen (Desulfovibrionales) (2/8 steps found)

KEGG Metabolic Maps

• Pyruvate metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.1.2.3

Use Curated BLAST to search for 1.1.2.3

Sequence Analysis Tools

See A9CFS2 at UniProt or InterPro

Protein Sequence (381 amino acids)

>Atu3871 L-lactate dehydrogenase (Agrobacterium fabrum C58)
MQLKDCYNFHDFRRMAKQRLPGPIFNYIDGAADDEVTYRRNTAAFENCDLVPDVLQGVAD
VDMSVTVMGQKLAMPVYCSPTALQRLFHHQGEKAVAAAAGKFGTMFGVSSLGTTSLEEAR
RISGGPQVYQFYFHKDRGLNRDMMARAKSAGVETMMLTVDSITGGNRERDKRTGFAIPFK
LNLSGIAQFAMKPAWGINYLTHERFSLPQLDDHIKMDGGALSISRYFTEMLDPSMNWDDV
ALMVREWGGPFCLKGIMSVDDARRAVEIGCSGIVLSNHGGRQLDGSRSAFDQLAEIVDAV
GDRIDVMMDGGVQRGTHVLKALSLGAKAVGLGRYYLFPLAAAGQPGVERALETMRIEIER
GMKLMGCTTVDQLTRRNLRFH