Protein Info for Atu3787 in Agrobacterium fabrum C58

Annotation: two component sensor kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 transmembrane" amino acids 404 to 422 (19 residues), see Phobius details amino acids 428 to 446 (19 residues), see Phobius details amino acids 451 to 467 (17 residues), see Phobius details amino acids 481 to 501 (21 residues), see Phobius details PF02702: KdpD" amino acids 26 to 234 (209 residues), 326.5 bits, see alignment E=1.9e-101 PF00582: Usp" amino acids 255 to 370 (116 residues), 25.7 bits, see alignment E=4.6e-09 PF13493: DUF4118" amino acids 405 to 511 (107 residues), 97.8 bits, see alignment E=9.3e-32 PF13492: GAF_3" amino acids 531 to 649 (119 residues), 66.4 bits, see alignment E=1.1e-21 PF00512: HisKA" amino acids 669 to 736 (68 residues), 57.1 bits, see alignment 4.6e-19 PF02518: HATPase_c" amino acids 781 to 890 (110 residues), 92.1 bits, see alignment E=9.5e-30

Best Hits

KEGG orthology group: K07646, two-component system, OmpR family, sensor histidine kinase KdpD [EC: 2.7.13.3] (inferred from 100% identity to atu:Atu3787)

Predicted SEED Role

"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7CTB1 at UniProt or InterPro

Protein Sequence (900 amino acids)

>Atu3787 two component sensor kinase (Agrobacterium fabrum C58)
MPDDISDMPSRPSPDALLENAQREARGRLKIFLGAAPGVGKTYEMLMSGRAKLADGVDTV
IGVVETHGRRETEALVEGLSVVPRKRIDYRGQVLEEMDIDAILARRPALVLVDELAHTNA
AGSRHPKRYMDVQEILAQGINVYTTLNIQHVESLNDVVAQITRIRVRETVPDSIIDRADD
VEIIDITPDDLIKRLQDGKVYLPRTARRAIENYFSRGNLTALRELALRRTAQRVDEQLLN
HMQSHAISGPWAAGDRVLVCLDHGRNGPGLVRYARRQADRLRAPWTALHLDTPRSQQLSE
AEKDRLAGTMRLAQQLGGETVTLPALDLTREIIAYANANNFTHIIIGRPRKSWWQRIFQR
SLTHDLIDHAGDISVHVISGDKNEEKPGQAVKLAPARSPQSFRSYLNSTLFVGLAIIVGI
VLDQTLDVQNLALVFLMAVLAAAVRGGLGPALYASLLGALAFNFFFLEPRYTLTVSSPDS
LVALLFYFGVALVASNLTVAVQRQAASARSRARTTEDLYLFSKKLAGTGTLDDVLWAAAY
QMASMLKVRVVLLMPENGAIAVKAGYPPDDTLVDADIAAAQWAWEHNKAAGRGADTLPGA
KRLYLPLRTGSGAVGVVGLDDDRSGPLLTPEQQRLFDALADQAALAVERIQLASDVDRAR
LAAETDRLRTALLTSISHDLKTPLAAILGSAGTLKDFADDIPPDARAELLSTIVEESERL
NRFISNLLDMTRIGSGAMEPNYGLHFLGDMVGTALSRAAKIVVRHEVVLDIPSDLPMLKV
DPVLFEQVLFNLIDNAAKYAPEHTTIAIRGWRQGKNIFLSVADEGPGIPPDDLERVFDSF
YRVRKVDHVQAGTGLGLSICKGFIEAMGGSIRAENRADRGGAQFTIGLPVAVDTPVLDHD