Protein Info for Atu3274 in Agrobacterium fabrum C58

Annotation: AcrB/AcrD/AcrF family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1046 signal peptide" amino acids 1 to 36 (36 residues), see Phobius details transmembrane" amino acids 333 to 352 (20 residues), see Phobius details amino acids 359 to 380 (22 residues), see Phobius details amino acids 386 to 410 (25 residues), see Phobius details amino acids 430 to 455 (26 residues), see Phobius details amino acids 462 to 485 (24 residues), see Phobius details amino acids 526 to 542 (17 residues), see Phobius details amino acids 854 to 872 (19 residues), see Phobius details amino acids 879 to 899 (21 residues), see Phobius details amino acids 904 to 925 (22 residues), see Phobius details amino acids 955 to 973 (19 residues), see Phobius details amino acids 983 to 1007 (25 residues), see Phobius details PF00873: ACR_tran" amino acids 3 to 1008 (1006 residues), 976.6 bits, see alignment E=1.4e-297 PF03176: MMPL" amino acids 208 to 491 (284 residues), 30 bits, see alignment E=2.8e-11

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 100% identity to atu:Atu3274)

Predicted SEED Role

"Acriflavin resistance protein" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CEY4 at UniProt or InterPro

Protein Sequence (1046 amino acids)

>Atu3274 AcrB/AcrD/AcrF family protein (Agrobacterium fabrum C58)
MIPNFCINRPVATTLLAIGLVLAGLAGFRLLPVAALPKVDFPTINVSSSLSGASPQTMAT
SVTTPLVKQFETIPGVSEISATNTLGNSSIVLQFDLNRDIDAAAADVQAAISRAQRQLPS
NMTTTPSYRKTNPADAPVLLLAVNSKEMPTSKVDEIAENIISPLLSTISGVAQVSIYGAQ
TYAVRIGLDPTQLQARGLGVDTVTTAITQANNQVPVGALQTDNQRLTIEADTQRTNAAAF
RSLVVSTNNGAPIHLGDIANVTDSIDNTNAGSWFDGEQAIILAVQRQPDANTVEVVDAIK
AKLPALQQQLPPSVNIHVMNDASTAIKDAISDVQFTLFLTIGLVVAVIYLFTGHLTATII
PGLAVPLSLITAFGMMYVLGYSIDNISLLGLTLSVGLVVDDAIVMLENILRLHEKGLPMR
EAALQGAAEVSGTILSMSVSLVAVFIPILLMGGVIGRLFNEFGMVVTLAIMASALVSLTV
TPMLASRLSGHSSRPPAIIRWFDAGFERTLRLYGKAVGWCLSHRRIVLASFLASVAASVY
LFETLPSSFFPQEDIGRLSVSTQAREDISYTAMRDLQAQVADQIRKNPAVVHVTSIVGGN
SRNPLNNGSMFVELKPKEERAPISQVLTELGQATSKVAGIRTYINPQQSLRFGGRSSASQ
YQLVVQGLNADTTNEWSNKLMEAMRRDHTFTAVTTDAQNGAIAATISVDPEKAAAFGITN
DQLRKTLEMSFGGYTAAQIQSTGDSYDVIVEFDSSKSWNDDFLSDINILSAKSGVLVPLS
NFASLTRTQAPVTINQTGQLVSTTISFNLPDGVALSDATSRIDQIKTTIGLPQDVFTSYG
GTAAIFQQSQGNTGVLILAAVLTIYVVLGVLYESFIHPLTILSGLPAAAFGALVALKVMG
MDFSIIALIGLLMLIGIVKKNAIMMIDVAVELMREKAEPPAIAIHEACVRRFRPIMMTTF
CALLGALPIALGSGASSELRQPLGIAVVGGLIVSQLLTLFITPVIFVEMDRFGHFLTGLF
SRKKNVEPHAEQQKPRRKAEPDSVAA