Protein Info for Atu2804 in Agrobacterium fabrum C58

Annotation: cobaltochelatase subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1116 PF02514: CobN-Mg_chel" amino acids 141 to 689 (549 residues), 466.5 bits, see alignment E=9.7e-144 amino acids 697 to 1097 (401 residues), 425.2 bits, see alignment E=2.9e-131

Best Hits

KEGG orthology group: K02230, cobaltochelatase CobN [EC: 6.6.1.2] (inferred from 100% identity to atu:Atu2804)

Predicted SEED Role

"CobN component of cobalt chelatase involved in B12 biosynthesis" in subsystem Coenzyme B12 biosynthesis

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.6.1.2

Use Curated BLAST to search for 6.6.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CHC2 at UniProt or InterPro

Protein Sequence (1116 amino acids)

>Atu2804 cobaltochelatase subunit (Agrobacterium fabrum C58)
MHILATTSSSLDDLIEPVDLNQPRSDVVVLSFSASDLAGLERAWGKAGETLPSLSAANLS
ELRHPMSVDLWIEKTAEHARVILIRILGGAERWRYGVDQLAILARRRGIKLLLLPGECSE
RDEKLEAASTVDKPMLASVLSFFREGGRENMGRLAAGLSVLAGGGEWPDIKADPLPKAGF
YRPDLGVVGQDEACAGFPAGASVLPILFYRSMLLAEDAAPVDALFQALSARGFAPLPIFV
SGLKDGEAIRFLETVLPALQPAAIIAATAFASHTDDRGETLFDRLGVPVFQAVMATTRRV
GWVENARGLNPSDLAMHVVLPELDGRILTGAISFKQARTDGGVSLVNVPEADRIEQVANR
IAAFLRLKSAPPRDRRIVILMPDYPGAAPGRTGYAVGLDVPQSVLEMLRDLAEAGYAVED
IPETARALLDRIESQEATVDLSTYRDFFAGLTETASSSMNATWGAAEQDDAFADGAFHFR
VARFGQVFVALAPDRGRNEDRRVDYHDPALPPRHALVAFGAWMQSVVATHAIVHVGAHGT
LEWLPGKTVALSRDCFPEIVTGPLPVVYPFIVSNPGEAAVAKRRIAAVTIGHVPPVLVNA
GLSPEQLALEQLVDEYAQADGLDRRRRDRLAKLIVEKALETGLAAEAGVGAKDDADAALS
RIDAFLCDLKDFAIKDGQHVFGRSPEGEADPLRLQSAKAEKAALLAALDGRHIAPGPSGA
PARGRLDVLPTGRNLYAADPRTMPTPTAFDLGRMAGEEVLRHHLQSHGDWPKHLVFDLWG
SASLRNGGEDVAQALHLMGARPIHDPATGRVTGIEVLPPASLGRPRVDVTFRISGLFRDM
FPALIALLDAAAKAVARRDEAPGDNPLAEEAAALGHIPARIFGSAPGTYGAGIEEKLASG
TWDEREELGQAYLDAANHAFGGADGLEIFEDAGFTELVRRADLLVHTGDDPGRDLLDGSS
DVAFIGGFSAAKAVLGGIADIVALDTTDPARPRARSMTQALTRVVRARAVNPRFIAGQMR
HGPRGAAEFAETVDRLVGFAETTHVVSSSLIEALYDAYFGNEEVRDFILRENPKAAEVMA
ARFLSARRRGLWHSRRNAVDAELEMLILPRSERVGA