Protein Info for Atu2582 in Agrobacterium fabrum C58

Annotation: UDP-glucose/GDP-mannose dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03446: NAD_binding_2
  • amino acids 1 to 128 (128 residues), 29.2 bits, E=1.8e-10
• PF03721: UDPG_MGDP_dh_N
  • amino acids 2 to 172 (171 residues), 149.7 bits, E=1.5e-47
• TIGR03026: nucleotide sugar dehydrogenase
  • amino acids 2 to 409 (408 residues), 417.9 bits, E=2e-129
• PF00984: UDPG_MGDP_dh
  • amino acids 195 to 285 (91 residues), 109.6 bits, E=1.4e-35
• PF03720: UDPG_MGDP_dh_C
  • amino acids 313 to 412 (100 residues), 72.8 bits, E=5.4e-24

Best Hits

Swiss-Prot: 53% identical to UGND_PSEAE: UDP-N-acetyl-D-glucosamine 6-dehydrogenase (wbpA) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K13015, UDP-N-acetyl-D-glucosamine dehydrogenase [EC: 1.1.1.-] (inferred from 100% identity to atu:Atu2582)

MetaCyc: 53% identical to UDP-N-acetyl-D-glucosamine 6-dehydrogenase monomer (Pseudomonas aeruginosa PAO1)
UDP-N-acetylglucosamine 6-dehydrogenase. [EC: 1.1.1.136]

Predicted SEED Role

No annotation

MetaCyc Pathways

• UDP-N-acetyl-α-D-galactosaminuronate biosynthesis (1/2 steps found)
• UDP-2,3-diacetamido-2,3-dideoxy-α-D-mannuronate biosynthesis (1/5 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (6/24 steps found)

KEGG Metabolic Maps

• Alkaloid biosynthesis I
• Aminosugars metabolism
• Ascorbate and aldarate metabolism
• Benzoate degradation via CoA ligation
• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of type II polyketide products
• Biosynthesis of unsaturated fatty acids
• Bisphenol A degradation
• Butanoate metabolism
• C21-Steroid hormone metabolism
• Fructose and mannose metabolism
• Glycine, serine and threonine metabolism
• Insect hormone biosynthesis
• Linoleic acid metabolism
• Nucleotide sugars metabolism
• Polyketide sugar unit biosynthesis
• Retinol metabolism
• Tetrachloroethene degradation

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.-

Use Curated BLAST to search for 1.1.1.- or 1.1.1.136

Sequence Analysis Tools

See Q7CWQ5 at UniProt or InterPro

Protein Sequence (424 amino acids)

>Atu2582 UDP-glucose/GDP-mannose dehydrogenase (Agrobacterium fabrum C58)
MIGLGYVGLPLAMTVAKAGFKVVGFDIDPGKITAIEAGRSYIEAVSDEVLASVRQDDGFV
ATSDFLRLAECDVIAICVPTPLTKYREPDLSYVEKTCRDIAAHLRKGQLVVLESTTYPGT
TDGVVKTILESTGLVSGVDFFIGFSPEREDPGNRDFETSTIPKVVAGDGEAAGKLMAAFY
GSVVKKIVPVSTNATAEAVKITENVFRAVNIALVNELKVVYEAMGIDIWEVIDAAKTKPF
GFMPFYPGPGLGGHCIPIDPFYLTWKSREYELPTRFIELAGEINTGMPRHVVGRVAEALD
IHSGKALSRSKVLVVGLAYKKNVPDIRESPSLKLLELIQERGGDAAYFDPYVAEIPKTRE
YSHLMGMKSISWDRETIGSFDAVLVATDHDNVDYAALSDWAPLIIDTRNVFARRDIAAKH
IIKA