Protein Info for Atu2580 in Agrobacterium fabrum C58

Annotation: adenylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 564 signal peptide" amino acids 1 to 36 (36 residues), see Phobius details transmembrane" amino acids 59 to 78 (20 residues), see Phobius details amino acids 90 to 109 (20 residues), see Phobius details amino acids 139 to 160 (22 residues), see Phobius details amino acids 169 to 189 (21 residues), see Phobius details amino acids 228 to 249 (22 residues), see Phobius details PF00111: Fer2" amino acids 268 to 344 (77 residues), 30 bits, see alignment E=3.9e-11 PF00211: Guanylate_cyc" amino acids 372 to 555 (184 residues), 73.3 bits, see alignment E=2e-24

Best Hits

KEGG orthology group: K01768, adenylate cyclase [EC: 4.6.1.1] (inferred from 100% identity to atu:Atu2580)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1

Use Curated BLAST to search for 4.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CHM3 at UniProt or InterPro

Protein Sequence (564 amino acids)

>Atu2580 adenylate cyclase (Agrobacterium fabrum C58)
MIRFFSETNLRRARIASGLILFAFVFSHLSNHSLALISIDTAERARKWFSLIWLNPVSSL
LFYGSVVVHVCLVLRSLYLRRTLRMPLREALQVIFGLSIPFLIIGHAVNIRASHMLYGID
VGYYSVIRRLWINNPVSGAWQSLALIVIWTHGCIGLYFWLRYRDWYPKIAGLFMTVAVML
PLLALLGFSDAGRWLEEVDRKYALPPGLTDNTIQRDELPLQREMETRIRFITGATEAIFA
GAVMLVFVLRGVRSFRQRLTAIEIHYEQGVQARIPAGFSILEASRLAGIPHYSVCGGKGR
CSTCRVKVLNSKGPLPPPGDIEQTTLRRIHADSDVRLGCQLRPTSDLDIALLVSPPQQSD
LPADAQSARPGREEEIAILFCDLRNFTTLSEAKLPYDVVFLLNRYFTIVGQAVEQADGHL
DKFIGDGAMALFGLGEDTDRACRNAMKAAATILRDIAILNEGLEKQFAVRLEVVVGIHSG
PSIVGVMGYGAAKTLTAIGDTVNVASRLESKAKEFGAAIVVSEPAIIQAGQDIADLRSEN
IAIRGRNSQMKVYLLSREESERYL