Protein Info for Atu2486 in Agrobacterium fabrum C58

Annotation: cardiolipin synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 486 transmembrane" amino acids 6 to 26 (21 residues), see Phobius details amino acids 38 to 60 (23 residues), see Phobius details amino acids 325 to 345 (21 residues), see Phobius details PF13091: PLDc_2" amino acids 137 to 244 (108 residues), 46 bits, see alignment E=7.1e-16 amino acids 330 to 445 (116 residues), 91.1 bits, see alignment E=8.4e-30 PF00614: PLDc" amino acids 401 to 426 (26 residues), 35.5 bits, see alignment (E = 1e-12)

Best Hits

KEGG orthology group: K06131, cardiolipin synthase [EC: 2.7.8.-] (inferred from 100% identity to atu:Atu2486)

Predicted SEED Role

"Cardiolipin synthetase (EC 2.7.8.-)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 2.7.8.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.8.-

Use Curated BLAST to search for 2.7.8.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CHR9 at UniProt or InterPro

Protein Sequence (486 amino acids)

>Atu2486 cardiolipin synthase (Agrobacterium fabrum C58)
MLDLVIAYWPHILAVLSILMGTVAAVHATMTKEEVRSALGWVGVIVLSPIVGAVIYAIAG
INRIRRSNITQQRSFMLDEIMDRVARLDASNDMIATRFGRRFEAMKTLGDRVTRHALTTG
NGIEPLVSGDVAYAAMLEAIGEAKRSIILETYIFDNDRIGARFVAALERAKLRGVEVRVL
IDAVGARYSVPSILPTLRDKDIVADVFNGNVIMGLRLPYANLRTHRKILVVDGRIAFSGG
MNIREGFTLEFGGESQSHDTHFKITGPVVSDFFSIAAEDWRFTTGEVLDAPVWDIAIPDG
VPGSQIVARVCSSGPDKSIETSHKMLMGAFSVARSSILIMSPYFLPDRELISALITAARR
GCVVDIIVPKSNNLVLVDRAMTAQFDQMLKNYCRIWRATGAFNHSKLLVIDGRWSYIGSS
NLDPRSLRLNFEIDLEVMDEEFAGAIGDRIRNARATALPVRLSELNARPFVVRFVERVLW
LASPYL