Protein Info for Atu2242 in Agrobacterium fabrum C58

Annotation: ABC transporter, nucleotide binding/ATPase protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 616 transmembrane" amino acids 37 to 60 (24 residues), see Phobius details amino acids 80 to 100 (21 residues), see Phobius details amino acids 156 to 178 (23 residues), see Phobius details amino acids 184 to 203 (20 residues), see Phobius details amino acids 268 to 292 (25 residues), see Phobius details amino acids 296 to 312 (17 residues), see Phobius details PF00664: ABC_membrane" amino acids 40 to 309 (270 residues), 59.7 bits, see alignment E=3.8e-20 PF00005: ABC_tran" amino acids 378 to 531 (154 residues), 115.5 bits, see alignment E=3e-37

Best Hits

Swiss-Prot: 54% identical to Y1051_HAEIN: Uncharacterized ABC transporter ATP-binding protein HI_1051 (HI_1051) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K06147, ATP-binding cassette, subfamily B, bacterial (inferred from 100% identity to atu:Atu2242)

Predicted SEED Role

"Lipid A export ATP-binding/permease protein MsbA" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7CXJ3 at UniProt or InterPro

Protein Sequence (616 amino acids)

>Atu2242 ABC transporter, nucleotide binding/ATPase protein (Agrobacterium fabrum C58)
MFGWFEKRLDPFPSSTPDVPPKTLLSFIWHYVKPAWPWLLLLGLMSMGIAIAEAMLYKFL
GNIVDWLSTANRETFFADEGWHLIVMAGLVLFLLPLMGAIHTMTMHQTLAGNFGMIARWK
MHRFLLRHSMNFFANEFAGRVSTKVMQTALAIREVALKVIDVFVYAISFVVSMLFMVAAA
DWRLVIPLLIWLGIYMAILAYFVPKLGRLAQEQADARSMMTGRIVDSYTNISTIKLFSHA
GREERYAREGMNVFLGTVHRQMRKISGFNILIDLNNAVVLFSTATLGLYFWMQGSVTAGS
VAIAISLAMRVNGMSQWIMWEVTSLFENIGTVYDGMSMMTKPHDIVDVPKAPELAAPQGA
IHYDNVRFHYGKNKGVIDGLTLDIKPGEKVGLVGRSGAGKTTLMNLLLRFYDLEGGRITI
DGQDISKVSQDSLRELIGVVTQDTSLLHRSIRDNIAYGHPEATDEQVIAAAKRANAWDFI
ETLVDMHGRQGLDAQVGERGVKLSGGQRQRIAIARVFLKNAPILVLDEATSALDSEVEAA
IQENLFSLMEGKTVIAIAHRLSTLTEMDRLIILDKGRIVEAGSHAELAAMGGIYADLWRR
QSGGFIADHGAEVAAE