Protein Info for Atu2226 in Agrobacterium fabrum C58

Annotation: GGDEF family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 694 transmembrane" amino acids 16 to 35 (20 residues), see Phobius details amino acids 47 to 72 (26 residues), see Phobius details amino acids 84 to 105 (22 residues), see Phobius details amino acids 112 to 133 (22 residues), see Phobius details amino acids 145 to 165 (21 residues), see Phobius details amino acids 175 to 195 (21 residues), see Phobius details amino acids 213 to 236 (24 residues), see Phobius details PF03707: MHYT" amino acids 58 to 112 (55 residues), 48.2 bits, see alignment 1.3e-16 amino acids 120 to 168 (49 residues), 47.3 bits, see alignment 2.6e-16 amino acids 183 to 235 (53 residues), 23.4 bits, see alignment 7.4e-09 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 251 to 410 (160 residues), 115.5 bits, see alignment E=9.9e-38 PF00990: GGDEF" amino acids 254 to 406 (153 residues), 133.5 bits, see alignment E=9.5e-43 PF00563: EAL" amino acids 431 to 660 (230 residues), 250.6 bits, see alignment E=2.2e-78

Best Hits

KEGG orthology group: None (inferred from 100% identity to atu:Atu2226)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CI56 at UniProt or InterPro

Protein Sequence (694 amino acids)

>Atu2226 GGDEF family protein (Agrobacterium fabrum C58)
MFKVLQCLTIDHDYRYTAAAVVVCMLGSFVTMRLFSKARLATGLQKVNWLFLAGVNGGAA
IWTTHFVAMLGYVAAGDVGYDPYLTGLSLLIAITTTTAGFGISAYGGRSVLVEAGGTILG
LGIAAMHYTGMAAYNVQGMIFWDQAYVIASLVLGSVLGAIAVNRIARPLNRFCQYSAVAF
LILAIASMHYTGMASMSFAFDPRIIIPENLLPPAIMGGGAIAVTLLLLALGLSTYVIDAQ
STQQAVARYRHLSLHDPLTGIPNRAAFIEHLNRRTRHISMGAHTALLSIDLDRFKEINDV
HGHAAGDAVLRAIADRASSVLKAGEFLARMGGDEFVAMTHSYYTRADGAEFAQRLIEQIS
KPVEWNGQTFSVGASVGISVRNTGSIDADTLMAQADVAMYRAKSATSDTICFYDKSMDEA
ARARNALAIAMRSGLANNEFELYYQQQNDTKSGSIVGFEALLRWKHPERGMVSPVEFIPI
AEQTGFIVELGEWVLREACAQAARWKKSLAIAVNVAPQQLADNDFPDKVERILAETGLAP
ERLELEITEGSIIADHRHALVTIRKLKSLGVKIAMDDYGTGYSSLSTLQSFPFDKIKIDR
AFIDGLSTNVQSEAIVRSTLILAHSLNIPVLAEGVETKAHIEFLRREGCLQVQGFFFGKP
GPLTSIANLVDDTFLSAEDETEEASGRRYIKVVR