Protein Info for Atu2124 in Agrobacterium fabrum C58

Annotation: transcriptional regulator, ArsR family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 337 PF12840: HTH_20" amino acids 17 to 63 (47 residues), 36.1 bits, see alignment 3.7e-12 PF12802: MarR_2" amino acids 18 to 64 (47 residues), 38.2 bits, see alignment 9.1e-13 PF01022: HTH_5" amino acids 18 to 62 (45 residues), 49.3 bits, see alignment 2.5e-16 PF01047: MarR" amino acids 18 to 65 (48 residues), 24.7 bits, see alignment 1.2e-08 PF13412: HTH_24" amino acids 19 to 62 (44 residues), 29.4 bits, see alignment 3.3e-10 PF01135: PCMT" amino acids 135 to 223 (89 residues), 22.3 bits, see alignment E=7.2e-08 PF00891: Methyltransf_2" amino acids 141 to 255 (115 residues), 22.4 bits, see alignment E=4.8e-08 PF01209: Ubie_methyltran" amino acids 144 to 264 (121 residues), 40.5 bits, see alignment E=1.4e-13 PF05175: MTS" amino acids 145 to 254 (110 residues), 25.4 bits, see alignment E=7e-09 PF13489: Methyltransf_23" amino acids 154 to 291 (138 residues), 49.5 bits, see alignment E=2.9e-16 PF13847: Methyltransf_31" amino acids 155 to 257 (103 residues), 78 bits, see alignment E=4.3e-25 PF13649: Methyltransf_25" amino acids 157 to 249 (93 residues), 76.9 bits, see alignment E=1.1e-24 PF08242: Methyltransf_12" amino acids 157 to 251 (95 residues), 58.5 bits, see alignment E=6.7e-19 PF08241: Methyltransf_11" amino acids 157 to 253 (97 residues), 84 bits, see alignment E=6.6e-27

Best Hits

KEGG orthology group: K03892, ArsR family transcriptional regulator (inferred from 100% identity to atu:Atu2124)

Predicted SEED Role

"Transcriptional regulator, ArsR family / Methyltransferase fusion"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CI99 at UniProt or InterPro

Protein Sequence (337 amino acids)

>Atu2124 transcriptional regulator, ArsR family (Agrobacterium fabrum C58)
MAFGLDKLVDLLKAAGEPTRFRLLALLSAGDLTVTDLTEILGQSQPRISRHLKLLTEEGL
IERYQEGAWAYFRLRQDGEPAVVVRQLLGAASPSDAVLQRDSERLATVKRVRAERAQDYF
SRNASAWDELRRLHVSDEAVEGALLKLVGTTPIDSLLDLGTGTGRILQLLSGIYRRAIGV
DASRDMLSVARANLDKAGVGNASVRHGDILNLPLEGQDFDLIVIHQVLHFLDQPEIALSE
AARMLRPGGRLIVIDLAPHSFEYLRDEHAHVRLGFSHPLMEEWMKKAGLSLERAVDLHSE
KASDEALDVTIWVARDQRLLMADDVVQEAVLLRSGRA