Protein Info for Atu2120 in Agrobacterium fabrum C58

Annotation: O-methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 221 PF01209: Ubie_methyltran" amino acids 23 to 149 (127 residues), 41.3 bits, see alignment E=4e-14 PF13489: Methyltransf_23" amino acids 33 to 161 (129 residues), 51.3 bits, see alignment E=4.2e-17 PF13847: Methyltransf_31" amino acids 34 to 154 (121 residues), 57.3 bits, see alignment E=5.4e-19 PF08242: Methyltransf_12" amino acids 39 to 138 (100 residues), 58.7 bits, see alignment E=2.9e-19 PF13649: Methyltransf_25" amino acids 39 to 136 (98 residues), 59.8 bits, see alignment E=1.2e-19 PF08241: Methyltransf_11" amino acids 39 to 139 (101 residues), 51 bits, see alignment E=6.6e-17

Best Hits

KEGG orthology group: K13623, S-adenosylmethionine-diacylgycerolhomoserine-N-methlytransferase (inferred from 100% identity to atu:Atu2120)

MetaCyc: 49% identical to diacylglycerolhomoserine N,N,N-trimethyltransferase (Cereibacter sphaeroides)
2.1.1.M42 [EC: 2.1.1.M42]

Predicted SEED Role

"Mlr1575 protein"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.1.M42

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CIA1 at UniProt or InterPro

Protein Sequence (221 amino acids)

>Atu2120 O-methyltransferase (Agrobacterium fabrum C58)
MDRMYRHQRHIYDITRKYYLLGRDRTISGLDVPKGGTLLEIGCGTGRNLLLASRRFPDAK
LFGLDISAEMLLTASENFAGKAERPILRVADATAFRSSEFGQPDGFDRVMIPYALSMIPD
WEKAIEQALAALKPGGSLHIVDFGQQEQLPKWFRTLLQAWLTRFHVTPRANLRYVLANMA
GRFDGNLVFEEIARGYAWRAVITLPVAEAPQPKIHRLLADA