Protein Info for Atu2094 in Agrobacterium fabrum C58

Annotation: UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 378 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details TIGR01133: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase" amino acids 5 to 356 (352 residues), 269 bits, see alignment E=3e-84 PF03033: Glyco_transf_28" amino acids 6 to 142 (137 residues), 113 bits, see alignment E=1.2e-36 PF04101: Glyco_tran_28_C" amino acids 187 to 351 (165 residues), 126.7 bits, see alignment E=9.7e-41

Best Hits

Swiss-Prot: 100% identical to MURG_AGRFC: UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (murG) from Agrobacterium fabrum (strain C58 / ATCC 33970)

KEGG orthology group: K02563, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC: 2.4.1.227] (inferred from 100% identity to atu:Atu2094)

Predicted SEED Role

"UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227)" in subsystem Peptidoglycan Biosynthesis (EC 2.4.1.227)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.1.227

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8UDM8 at UniProt or InterPro

Protein Sequence (378 amino acids)

>Atu2094 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (Agrobacterium fabrum C58)
MNKGIVLLAAGGTGGHVFPAEALAHTLKARGYQVHLVTDSRAERYAGKFPADEIHVVPSA
TIGSKNPISVVRSLWKLWVGLRTARRLVTKLKPVAVVGFGGYPTVPPLLASTGLGVPSII
HEQNAVMGRANKALAARVKAIAGGFLPPANGQYSEKTVATGNPVRPAVLAASEIPYTPSQ
TGETFQLVVFGGSQGAQFFSSAVPAAICLMKDEQRKRIVVTQQARPEDKDSVIASYQKLG
VKADVSPFFGDMASRIGEADLVISRSGASTVSELSVIGRPSILVPYPHALDHDQAANAAA
LSAAGGASVIKQAELSPQKLSSLLSSALAEPDRLSATAAAAKATGKPHAADVLADLVEAI
AEGRSVQEFKKKNEGVGA