Protein Info for Atu2059 in Agrobacterium fabrum C58

Annotation: transcriptional regulator, TetR family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 197 TIGR03384: transcriptional repressor BetI" amino acids 4 to 189 (186 residues), 238.3 bits, see alignment E=2.6e-75 PF00440: TetR_N" amino acids 16 to 59 (44 residues), 47.2 bits, see alignment 1.5e-16 PF13977: TetR_C_6" amino acids 82 to 188 (107 residues), 101 bits, see alignment E=4.7e-33

Best Hits

Swiss-Prot: 38% identical to BETI_SERP5: HTH-type transcriptional regulator BetI (betI) from Serratia proteamaculans (strain 568)

KEGG orthology group: K02167, TetR/AcrR family transcriptional regulator, transcriptional repressor of bet genes (inferred from 100% identity to atu:Atu2059)

Predicted SEED Role

"HTH-type transcriptional regulator BetI" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7CXZ1 at UniProt or InterPro

Protein Sequence (197 amino acids)

>Atu2059 transcriptional regulator, TetR family (Agrobacterium fabrum C58)
MRLTKISDIRRAELRRAAFEVLQREGMAGATLERVAAQAGASKGIVLHYFASKQELFEHA
MREANVKLAEVVVARLNRATSPRERLEAIIEANFDESFFQPSICHAWLSLCAEVPREPQL
GRIQKVIHARMRSNLLSALRHLVPKGDCEPIALGITTLIDGLWLRSGLQSGGLSREEALA
QMRDYLLHRLPSPEAAA