Protein Info for Atu2043 in Agrobacterium fabrum C58

Annotation: htrA family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 514 signal peptide" amino acids 1 to 35 (35 residues), see Phobius details TIGR02037: peptidase Do" amino acids 41 to 380 (340 residues), 443.3 bits, see alignment E=4.8e-137 PF00089: Trypsin" amino acids 102 to 258 (157 residues), 71.1 bits, see alignment E=3.2e-23 PF13365: Trypsin_2" amino acids 103 to 237 (135 residues), 124.4 bits, see alignment E=1.6e-39 PF00595: PDZ" amino acids 272 to 354 (83 residues), 37.4 bits, see alignment E=6.8e-13 amino acids 417 to 471 (55 residues), 27.3 bits, see alignment 9.9e-10 PF13180: PDZ_2" amino acids 277 to 367 (91 residues), 55 bits, see alignment E=2e-18 PF17820: PDZ_6" amino acids 303 to 356 (54 residues), 27.9 bits, see alignment 3.9e-10 amino acids 446 to 470 (25 residues), 30.1 bits, see alignment (E = 8.2e-11)

Best Hits

KEGG orthology group: K01362, [EC: 3.4.21.-] (inferred from 100% identity to atu:Atu2043)

Predicted SEED Role

"HtrA protease/chaperone protein"

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.-

Use Curated BLAST to search for 3.4.21.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7CY03 at UniProt or InterPro

Protein Sequence (514 amino acids)

>Atu2043 htrA family protein (Agrobacterium fabrum C58)
MAVTLLSPFRSSIAAVAGIALVAGSLSAPVAARAQSHGPESVADLAEPLLDAVVNISTSQ
NVKTEGKGPVPPKLPEGSPFQEFFKDYFDSQKPEGGEKVNSLGSGFVIDPAGYVVTNNHV
IEGADAIEVIFPNGSKLKATLVGTDTKTDLSVLKVEPKTPLKAVKFGDSRSMRIGDWVMA
VGNPFGLGGSLTVGVISARGRNINAGPYDNFIQTDAAINKGNSGGPLFNMKGEVIGINTA
IISPSGGSIGIGFAVPTELAQNIVQQLIEFGETRRGWLGVRVQPVTDDVAASLGMDSAKG
ALISGVAKGGPVENGPIQAGDVVLKFDGKDINEMRDLLRIVAESPVGKEVDVVVYRDGKE
ETVKVKLGQLQDTTDEKASTDDPQGEDGDGSMVAPDDKDGGDDQAQDQTPEVREAPQTVL
GMNLVVLSNELRTEKGIAESVEGVLVASVDPGSPAEQKGMKAGDVIVEVGQDFMEVPGDV
LVRVNGLKSEGRKNAHMMVADAQGNLRVVALPLE