Protein Info for Atu1786 in Agrobacterium fabrum C58

Annotation: glucosamine-fructose-6-phosphate aminotransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01135: glutamine-fructose-6-phosphate transaminase (isomerizing)
  • amino acids 2 to 608 (607 residues), 774.4 bits, E=4e-237
• PF13522: GATase_6
  • amino acids 67 to 191 (125 residues), 66.3 bits, E=4.4e-22
• PF13537: GATase_7
  • amino acids 92 to 196 (105 residues), 53.3 bits, E=4.2e-18
• PF01380: SIS
  • amino acids 294 to 415 (122 residues), 83.5 bits, E=1.8e-27
  • amino acids 462 to 589 (128 residues), 91 bits, E=8.4e-30

Best Hits

Swiss-Prot: 100% identical to GLMS_AGRFC: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (glmS) from Agrobacterium fabrum (strain C58 / ATCC 33970)

KEGG orthology group: K00820, glucosamine--fructose-6-phosphate aminotransferase (isomerizing) [EC: 2.6.1.16] (inferred from 100% identity to atu:Atu1786)

Predicted SEED Role

"Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 2.6.1.16)

MetaCyc Pathways

• O-antigen building blocks biosynthesis (E. coli) (11/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (4/6 steps found)
• chitin biosynthesis (5/9 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis III (2/6 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (13/33 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (6/24 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Glutamate metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.16

Use Curated BLAST to search for 2.6.1.16

Sequence Analysis Tools

See Q8UEH1 at UniProt or InterPro

Protein Sequence (608 amino acids)

>Atu1786 glucosamine-fructose-6-phosphate aminotransferase (Agrobacterium fabrum C58)
MCGIVGIVGTQPVAERLVDALKRLEYRGYDSAGVATIDNGAMDRRRAEGKLFNLEKLVSE
KPLPGVVGIAHTRWATHGVPNEINAHPHFVDGVAVVHNGIIENFSELREELSAEGATFTT
QTDTEVVAQLLAKYTREGLGHREAMLKMLNHVTGAYALVVMFQDDPGTLLSARSGPPLAV
GYGRGEMFLGSDAIALSPFTNEITYLVDGDCAIVTRDGAEIIDFSGKPVKRERQISQATA
FVVDKGNHRHFMEKEIYEQPEVISHALSHYVDFATRTVKDADKAIDFASLSGLAISACGT
AYLSGLIGKYWFERYARLPVEIDVASEFRYREIPLVPTQAALFISQSGETADTLAALRYC
QQEGLKIGAVVNTRESTMARESDAIFPILAGPEIGVASTKAFTCQLAVLASLAVAAGKAR
GTLKPGEEKQLVQQLIEMPRIMSKVLNVIQPQIEALSRDLSRFKDVLYLGRGTSFPLALE
GALKLKEISYIHAEGYAAGELKHGPIALIDENMPVIVIAPHDRFFEKTVSNMQEVAARGG
RIIFITDEKGAAASKLETMATITLPNVDELIAPMVFSLPIQLLAYHTAVFMGTDVDQPRN
LAKSVTVE