Protein Info for Atu1632 in Agrobacterium fabrum C58

Annotation: dimethylglycine dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 837 transmembrane" amino acids 7 to 23 (17 residues), see Phobius details PF01266: DAO" amino acids 7 to 368 (362 residues), 245.8 bits, see alignment E=3.4e-76 PF16350: FAO_M" amino acids 371 to 424 (54 residues), 65.3 bits, see alignment 1.7e-21 PF01571: GCV_T" amino acids 427 to 724 (298 residues), 215.8 bits, see alignment E=2.2e-67 PF08669: GCV_T_C" amino acids 753 to 829 (77 residues), 59.9 bits, see alignment E=6.2e-20

Best Hits

KEGG orthology group: K00315, dimethylglycine dehydrogenase [EC: 1.5.99.2] (inferred from 100% identity to atu:Atu1632)

Predicted SEED Role

"Dimethylglycine dehydrogenase (EC 1.5.99.2)" (EC 1.5.99.2)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.5.99.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8U599 at UniProt or InterPro

Protein Sequence (837 amino acids)

>Atu1632 dimethylglycine dehydrogenase (Agrobacterium fabrum C58)
MKTHARAVVIGGGVVGVSTLYHLAKKGWSDSVLIERKELTSGSTWHAAGLLPLFNMSYSV
GQIHKYSVKFYEELQEETGMNVGFSKVSNIRLARTKDRWDEYMYYAGIAETIGVRVNMLT
PEQVKEIWPLCETDGLLGAIQHPDDGYIQPADLTQALAKGARDRGATIYRNTTVTAIEQL
EDGHWKVTTDKGEIIAEHIISCTGNFARKTGEMVGIDIPVIPVEHQYIVTEPHPAILERR
RQGLPEMGVLRESDSAWYMREEAGGLILGPYEVGAPVCYVDGPSDDSEYELFQEELDRLM
PHIETAMVRVPAFGEVGIKKVYNGAIAYTPDGNPIVGPAPGLKNFWLNEGHSFGITAAGG
AGWQLAEWIVDGEPTLDLMGVDPRRFGPHATEGYLIAKNEEAYANVFTMHYPDEERSAAR
PLKTTPVYDRLKKLGGVFGSVYGWERANWYAPEGYALREEDLGVGADVITSHNYAPPLDD
GRIVEKWSFRRSNYFEHVGNEVKNVTNNVGVLDMSAFAKMEVSGPGARAWLDSILANIVP
KKRGRIALTHLLTPNGGVKIEFTVYEWAPGRFYMVSAGGLEAHDHDVLRRLAPTDGSVVL
QPITQKYGVLVLAGPKSRDLLKKLTRTSLENKDFPWLTGKQISVGVATAHALRVNFVGEL
GWELHHPIEMQNYIFDRLMEAGAEFGIKPFGIRAMVSMSLEKSYRNMGRELSVEYNAYES
GLDRFLRPEKSFIGRDALVAYKEAGLKSVFSTLTVSGNTDVDARGSEAISDENGVLAGRV
TSGGFGWRIGKSIALAMLKPEYAAVGTKLKIRILGTLYDAEVVEESPFDTENALLRA