Protein Info for Atu1537 in Agrobacterium fabrum C58

Annotation: cytochrome-c oxidase, FixN chain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 540 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 34 to 52 (19 residues), see Phobius details amino acids 72 to 100 (29 residues), see Phobius details amino acids 120 to 139 (20 residues), see Phobius details amino acids 151 to 174 (24 residues), see Phobius details amino acids 186 to 208 (23 residues), see Phobius details amino acids 220 to 243 (24 residues), see Phobius details amino acids 264 to 285 (22 residues), see Phobius details amino acids 296 to 314 (19 residues), see Phobius details amino acids 333 to 354 (22 residues), see Phobius details amino acids 366 to 386 (21 residues), see Phobius details amino acids 405 to 425 (21 residues), see Phobius details amino acids 445 to 465 (21 residues), see Phobius details amino acids 478 to 496 (19 residues), see Phobius details amino acids 499 to 520 (22 residues), see Phobius details TIGR00780: cytochrome c oxidase, cbb3-type, subunit I" amino acids 68 to 527 (460 residues), 800.6 bits, see alignment E=2.6e-245 PF00115: COX1" amino acids 72 to 503 (432 residues), 406.5 bits, see alignment E=7.4e-126

Best Hits

Swiss-Prot: 97% identical to FIXN_AGRT7: Cytochrome c oxidase subunit 1 homolog (fixN) from Agrobacterium tumefaciens (strain T37)

KEGG orthology group: K00404, cb-type cytochrome c oxidase subunit I [EC: 1.9.3.1] (inferred from 100% identity to atu:Atu1537)

MetaCyc: 76% identical to cytochrome cbb3 oxidase subunit I (Rhodobacter capsulatus)
CYTOCHROME-C-OXIDASE-RXN [EC: 7.1.1.9]

Predicted SEED Role

"Cytochrome c oxidase subunit CcoN (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1 or 7.1.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7CZ11 at UniProt or InterPro

Protein Sequence (540 amino acids)

>Atu1537 cytochrome-c oxidase, FixN chain (Agrobacterium fabrum C58)
MNYTLETAIVALGAFLALLGAAFAHDSLFAAHMWVLFFTLVVSTVLLLRRVSFAPVDPAA
RARRNSEYFDEVVKYGVIATVFWGVVGFLVGVVVALQLAFPDLNIAPYFNFGRMRPLHTS
AVIFAFGGNALIATSFYVVQRTCRARLFGGNLGWFVFWGYNLFIIMAATGYLLGITQGRE
YAEPEWYVDIWLTIVWVAYLATFLGTILTRKEPHIYVANWFYLSFIVTIAMLHIVNNLAV
PVSFLGVKSYSAFSGVQDALTQWWYGHNAVGFFLTAGFLGMMYYFIPKQVNRPVYSYRLS
IIHFWALIFMYIWAGPHHLHYTALPDWAQTLGMVFSIMLWMPSWGGMINGLMTLSGAWDK
IRTDPIVRMMVMAVAFYGMATFEGPMMSIKAVNSLSHYTDWTIGHVHSGALGWNGMITFG
AIYYLTPKLWGRDRLYSLQLVNWHFWLATLGIVVYAAVMWVAGIQQALMWREYDSQGFLV
YSFAESVAALFPYYVMRALGGLMFLSGALIMAYNVTMTILGHQREEGASKGAAPSLQPAE