Protein Info for Atu1456 in Agrobacterium fabrum C58

Annotation: sulfite reductase (NADPH) hemoprotein beta-component

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03460: NIR_SIR_ferr
  • amino acids 52 to 110 (59 residues), 65.7 bits, 2.5e-22
  • amino acids 331 to 396 (66 residues), 44.2 bits, E=1.3e-15
• PF01077: NIR_SIR
  • amino acids 119 to 272 (154 residues), 170.5 bits, E=1.9e-54
  • amino acids 411 to 527 (117 residues), 46 bits, E=3.9e-16

Best Hits

KEGG orthology group: K00381, sulfite reductase (NADPH) hemoprotein beta-component [EC: 1.8.1.2] (inferred from 100% identity to atu:Atu1456)

Predicted SEED Role

"Sulfite reductase [NADPH] hemoprotein beta-component (EC 1.8.1.2)" in subsystem Cysteine Biosynthesis (EC 1.8.1.2)

MetaCyc Pathways

• superpathway of L-methionine biosynthesis (by sulfhydrylation) (12/12 steps found)
• superpathway of sulfate assimilation and cysteine biosynthesis (9/9 steps found)
• assimilatory sulfate reduction I (4/4 steps found)
• assimilatory sulfate reduction III (3/3 steps found)
• superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (7/10 steps found)

KEGG Metabolic Maps

• Sulfur metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.2

Use Curated BLAST to search for 1.8.1.2

Sequence Analysis Tools

See A9CJ21 at UniProt or InterPro

Protein Sequence (556 amino acids)

>Atu1456 sulfite reductase (NADPH) hemoprotein beta-component (Agrobacterium fabrum C58)
MYRYDEFDHAFVEGRVAQFRDQVERRLSGELAEDAFKPLRLMNGVYLQLHAYMLRVAIPY
GTLNSQQMRMLAHIARKYDRGYGHFTTRQNIQYNWPRLSDTPDILSELASVEMHALQTSG
NCIRNVTADHFAGAAADEVADPRPYAEILRQWSSVHPEFSFLPRKFKIAVTGAERDRAAI
QVHDIGLHLKKNDKGEIGFAVYVGGGQGRTPMIAKKIRDFLPEEDLLSYTTAVMRVYNLH
GRRDNKYKARIKILVHETGAEELARQVEVEFAELKNTELKLPDADIAAITAYFAPPALKD
RPEGWESLARWKRADEGFARFVEQNVAPHKHPDYGMVTISLKPIGGIPGDATDEQMELVA
DIAAEYAFDEIRISHEQNIILPHVALADLEPVYRALVGAGLATANAGLITDIIACPGLDY
CALANARSIPVAQEISTRFGAPERQAEIGELKIKISGCINACGHHHVGHIGLLGVEKKGA
ELYQITLGGSGDENTSIGEIIGRGFEPEKVTDAVETIVDTYLGLRLSKEETFLEAYRRVG
PQPFKDALYGSAAEAA