Protein Info for Atu1110 in Agrobacterium fabrum C58

Annotation: cytosol aminopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 497 PF02789: Peptidase_M17_N" amino acids 27 to 144 (118 residues), 84.9 bits, see alignment E=4.4e-28 PF00883: Peptidase_M17" amino acids 183 to 487 (305 residues), 420.9 bits, see alignment E=3.4e-130

Best Hits

Swiss-Prot: 100% identical to AMPA_AGRFC: Probable cytosol aminopeptidase (pepA) from Agrobacterium fabrum (strain C58 / ATCC 33970)

KEGG orthology group: K01255, leucyl aminopeptidase [EC: 3.4.11.1] (inferred from 100% identity to atu:Atu1110)

Predicted SEED Role

"Cytosol aminopeptidase PepA (EC 3.4.11.1)" (EC 3.4.11.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.4.11.1

Use Curated BLAST to search for 3.4.11.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8UGC8 at UniProt or InterPro

Protein Sequence (497 amino acids)

>Atu1110 cytosol aminopeptidase (Agrobacterium fabrum C58)
MSAKFDISFANSASLENALAIVLQASGEAQAVAGASEADPGGVIERASKISGFSAKSMAT
LDVIAPQGSSADRLLVIGLGKPSKLVAHDWLRAGGTAAAHFKKADKVVIYLDAPGVEVSA
EAAADFALGLLLRAYSFDAYKTKKKSDDEKTPKKVDVTIVTAAHKDAEKASAVSEAIAGG
VILARDLVNLPPNVLGPVEFAEKAEELRKLGVDVEILGEKELKKLGMNALLGVAQGSARP
PRLAVMQWNGGSKKDEPIAFVGKGVVFDTGGISLKPGLGMEDMKGDMGGAAAVTGLMHVL
AARKAKANVIGVIGLVENMPDGNAQRPGDIVTSMSGQTIEIINTDAEGRLVLADALWYTK
DRFNPKFMINLATLTGAITVALGNLQAGLFSNDDELATRLAEAGEATAEKLWRMPLGKDY
DKIIDSKFADMKNSSGRLAGSVTAAQFLKRFVGETPWAHLDIAGTAMGSPLTEINQSWGS
GYGVRLLNELVRAHYED