Protein Info for Atu0843 in Agrobacterium fabrum C58

Annotation: P type cation (metal) transporter, ATPase component

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 905 transmembrane" amino acids 300 to 308 (9 residues), see Phobius details amino acids 314 to 332 (19 residues), see Phobius details amino acids 341 to 361 (21 residues), see Phobius details amino acids 367 to 386 (20 residues), see Phobius details amino acids 517 to 538 (22 residues), see Phobius details amino acids 545 to 570 (26 residues), see Phobius details amino acids 854 to 879 (26 residues), see Phobius details amino acids 884 to 901 (18 residues), see Phobius details PF00403: HMA" amino acids 17 to 78 (62 residues), 62 bits, see alignment 1.1e-20 amino acids 121 to 181 (61 residues), 60.2 bits, see alignment 4.2e-20 TIGR00003: copper ion binding protein" amino acids 17 to 77 (61 residues), 37.9 bits, see alignment 4.2e-13 amino acids 121 to 180 (60 residues), 35.4 bits, see alignment 2.4e-12 TIGR01512: cadmium-translocating P-type ATPase" amino acids 347 to 686 (340 residues), 326.5 bits, see alignment E=7.3e-101 TIGR01525: heavy metal translocating P-type ATPase" amino acids 347 to 896 (550 residues), 600.8 bits, see alignment E=7.9e-184 TIGR01511: copper-translocating P-type ATPase" amino acids 365 to 896 (532 residues), 399.6 bits, see alignment E=6.6e-123 TIGR01494: HAD ATPase, P-type, family IC" amino acids 371 to 871 (501 residues), 266.2 bits, see alignment E=1.1e-82 PF00122: E1-E2_ATPase" amino acids 397 to 578 (182 residues), 186.4 bits, see alignment E=7.2e-59 PF00702: Hydrolase" amino acids 595 to 807 (213 residues), 122.1 bits, see alignment E=7.9e-39

Best Hits

KEGG orthology group: K01534, Cd2+/Zn2+-exporting ATPase [EC: 3.6.3.3 3.6.3.5] (inferred from 95% identity to atu:Atu0843)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7D0J8 at UniProt or InterPro

Protein Sequence (905 amino acids)

>Atu0843 P type cation (metal) transporter, ATPase component (Agrobacterium fabrum C58)
MNISTRGSLNGESEELTFKVGGMDCGSCAAKIETALSRLPGVADVKVSVARERLNLSLAE
NKTPVEKIEDTLRKLGFKPALLPRDKAPEAKAADHHDHSTCGGHHHDEAEIPAEKNNALI
FSVGGMDCGSCAAKIETALSRLPGVGDVKVSVARERLNLSLAENKTPVEKIEDTLRKLGF
KPALLPQEKTAREKTPEQNHDHDHATCGGHHHDHDHSGHDHAAHDHSGHDHQSCKGHDHD
HSDHDHSGHDHSGHDHAGQSHAAAPAAASQSAEIGHAHGADEKGAWWRSAKARNTFTGTV
LVAIAYAAELTFPAWGSYAFIVATLATLFPIARNAFNAARFGAVFTIEMLMTIAAIGAII
IGEAEEAAIVVLLFSVGELLEGFAAARARSGIKALGSLLPKTALVEENGSLRQIAADQVR
IGQVVVARPGDRIAADGVVMEGQSSVDESPMTGESIPVAKEKGARVFAGSINHDGSLRIR
VDRAPEDNTIARIITLVEEAQDARAPTERFIQSFSRYYMPLIVAISALTIVVPPLVGLGD
WDTWIYRGLALLLIGCPCALVISVPAAIASSLSAAARHGMLVKGGAVIEMLARTETVAFD
KTGTLTLGEPVVTDVVALDGNEAELIAQAATIENESSHPLARAIVSHANKAGVIPLPGSE
IKAISGRGMQGNVGGKRLFIGAPRFATDVGTVSNELAERISALESEGKTVAVVMAEGVAS
GLFAMRDEPRKDAAEGIKALKDMGISSLMLSGDNARTARAIGNKLGLEARGELLPQNKVE
EIRKLAEKKTVVMVGDGINDAPALAAASVGVAIGSGTDVAMEAADAALMRNNVGDAARLI
GLSRATMSNIRQNVTIALGLKAVFLVTTVTGVSGLWLAVFADTGATVLVTANAMRLLGYF
NGRKT