Protein Info for Atu0830 in Agrobacterium fabrum C58
Annotation: choline dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to BETA_AGRFC: Oxygen-dependent choline dehydrogenase (betA) from Agrobacterium fabrum (strain C58 / ATCC 33970)
KEGG orthology group: K00108, choline dehydrogenase [EC: 1.1.99.1] (inferred from 100% identity to atu:Atu0830)MetaCyc: 87% identical to choline dehydrogenase (Sinorhizobium meliloti Rm2011)
Choline dehydrogenase. [EC: 1.1.99.1]
Predicted SEED Role
"Choline dehydrogenase (EC 1.1.99.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.1.99.1)
MetaCyc Pathways
- choline-O-sulfate degradation (3/3 steps found)
- choline degradation I (2/2 steps found)
- glycine betaine biosynthesis I (Gram-negative bacteria) (2/2 steps found)
- glycine betaine biosynthesis II (Gram-positive bacteria) (2/2 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.1.99.1
Use Curated BLAST to search for 1.1.99.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q8UH55 at UniProt or InterPro
Protein Sequence (549 amino acids)
>Atu0830 choline dehydrogenase (Agrobacterium fabrum C58) MQADYVIVGSGSAGSAIAYRLSEDGRYSVIVIEAGGSDFGPFIQMPAALAWPMSMKRYNW GYLSEPEPNLDNRRITAPRGKVIGGSSSINGLVYVRGHAEDFNRWEELGAQGWAYADVLP YFKRMEHSHGGEEGWRGTDGPLHVQRGPVSNPLFHAFIQAGAQAGFELTDDYNGSKQEGF GLMEQTIHNGRRWSAANAYLKPALKRGNVTLVNGFARKVIIENGRAVGVEIERRGRVETV KANREVIVSASSFNSPKLLMLSGIGPAAHLKDMGIEVKADRPGVGANLQDHMEFYFQQVS TKPVSLYSWLPWFWQGVAGAQWLLSKGGLGASNQFEACAFLRSAPGLKQPDIQYHFLPVA ISYDGKAAAKSHGFQAHVGYNLSKSRGNVTLRSADPHDDPVIRFNYMSHPEDWEKFRHCV RLTREIFGQKAFDDFRGPEIQPGENIETDEQIDAFLREHLESAYHPCGTCRMGDRNDPMA VVDPECRVIGVEGLRVADSSIFPHVTYGNLNGPSIMTGEKAADHILGKTPLPRSNQEPWV NPRAAVSDR