Protein Info for Atu0699 in Agrobacterium fabrum C58

Annotation: DNA mismatch repair protein MutL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 606 TIGR00585: DNA mismatch repair protein MutL" amino acids 1 to 305 (305 residues), 302.9 bits, see alignment E=1.8e-94 PF02518: HATPase_c" amino acids 23 to 77 (55 residues), 28 bits, see alignment 5.1e-10 PF13589: HATPase_c_3" amino acids 24 to 117 (94 residues), 47 bits, see alignment E=5.3e-16 PF01119: DNA_mis_repair" amino acids 208 to 324 (117 residues), 129.5 bits, see alignment E=1e-41 PF08676: MutL_C" amino acids 422 to 562 (141 residues), 161.8 bits, see alignment E=1.7e-51

Best Hits

Swiss-Prot: 100% identical to MUTL_AGRFC: DNA mismatch repair protein MutL (mutL) from Agrobacterium fabrum (strain C58 / ATCC 33970)

KEGG orthology group: K03572, DNA mismatch repair protein MutL (inferred from 100% identity to atu:Atu0699)

Predicted SEED Role

"DNA mismatch repair protein MutL" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8UHI3 at UniProt or InterPro

Protein Sequence (606 amino acids)

>Atu0699 DNA mismatch repair protein MutL (Agrobacterium fabrum C58)
MAIKQLSETLINQIAAGEVIERPSSATKELVENAIDAGATRIEIATAGGGKGLVRITDNG
SGMSPADLELAVRRHCTSKISTTLDDIRTLGFRGEALPSIGSVAKLTITSRQQGAEQGSV
ISVTGGKVSDVRPAASNAGTIVEVRDLFFATPARLKFLKTERAEAAAITEVVKRMAIAFP
HIRFVLSGTDRSTLEIPSTGDDHLARMAQILGAEFKDNAIEIDAGREDVTLTGFAGVPTF
NRGNSSHQYVFVNGRPVQDKLLLSAIRGAYAETVPHGRYPVAVLSITLDPAFVDVNVHPA
KSDVRFRDPGLIRGLIVGAIRQALTRDGDRAATTGASQMMNAFRPGYSPSGLRPSPSATW
SAATSPSRPLAVSGDMQFAEAAQSRFSDITMPTARAEPREAYEASQSPSPEPVLYPLGAA
RAQLHENYIIAQTENGLVIVDQHAAHERLVFEEMRNALHSRRPPSQVLLIPEIIDLPEED
CDRLMDHAAGFDALGLVIERFGPGAIAVRETPAMLGEVNVQGLVRQLADEIAEWDAASTL
ANKLEYVAATMACHGSVRSGRRMRPEEMNALLRQMENTPGSGQCNHGRPTYIELKLSDIE
RLFGRS