Protein Info for Atu0182 in Agrobacterium fabrum C58

Annotation: transcriptional regulator, GntR family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 245 TIGR02325: phosphonate metabolism transcriptional regulator PhnF" amino acids 7 to 245 (239 residues), 373.2 bits, see alignment E=2.7e-116 PF00392: GntR" amino acids 17 to 78 (62 residues), 57 bits, see alignment E=1.2e-19 PF07702: UTRA" amino acids 101 to 239 (139 residues), 108.1 bits, see alignment E=3.2e-35

Best Hits

Swiss-Prot: 55% identical to Y6150_RHIME: Uncharacterized HTH-type transcriptional regulator RB1450 (RB1450) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K02043, GntR family transcriptional regulator, phosphonate transport system regulatory protein (inferred from 100% identity to atu:Atu0182)

Predicted SEED Role

"Transcriptional regulator PhnF" in subsystem Alkylphosphonate utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CKL6 at UniProt or InterPro

Protein Sequence (245 amino acids)

>Atu0182 transcriptional regulator, GntR family (Agrobacterium fabrum C58)
MSPVAAMKRKNGVALWRQIADRIRGEIAAGDHDETGMLPPEMTLAEKFGVNRHTVRSAIA
ALASEGILEPMQGRGTMIARKERLSFPISLRTRFTAGIGDQVKEMEALLLSHTTEPASAD
LAARLQLPSGAPLVRLETLRKADTRPVSRSTTWFPADRFAGIGEAYRKSGSITAAFKALG
VADYVRISTVISAIHADTQDLADLELSPGAILLVTQALNADMDGVPVQYAVSRFSADTVE
FTVEN