Protein Info for Atu0127 in Agrobacterium fabrum C58

Annotation: ABC transporter, nucleotide binding/ATPase protein (sugar/ribonucleotide)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 501 PF00005: ABC_tran" amino acids 21 to 168 (148 residues), 105.8 bits, see alignment E=3e-34 amino acids 273 to 429 (157 residues), 69.2 bits, see alignment E=6.2e-23

Best Hits

Swiss-Prot: 51% identical to YUFO_BACSU: Uncharacterized ABC transporter ATP-binding protein YufO (yufO) from Bacillus subtilis (strain 168)

KEGG orthology group: K02056, simple sugar transport system ATP-binding protein [EC: 3.6.3.17] (inferred from 100% identity to atu:Atu0127)

Predicted SEED Role

"Predicted nucleoside ABC transporter, ATP-binding component" in subsystem D-ribose utilization or Deoxyribose and Deoxynucleoside Catabolism

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.17

Use Curated BLAST to search for 3.6.3.17

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7D253 at UniProt or InterPro

Protein Sequence (501 amino acids)

>Atu0127 ABC transporter, nucleotide binding/ATPase protein (sugar/ribonucleotide) (Agrobacterium fabrum C58)
MDPAIELMGIDKKFGAVHANKNINLSVAKGTIHGIIGENGAGKSTLMSILYGFYQADAGE
IRVNGKPVTIRDSQAAISAGIGMVHQHFMLVENFTVLENVMLGAEGGALLARGRAGARRE
LKRLEDDYGLEVDPDAVIEELPVGLQQRVEILKAMYRGAEILILDEPTGVLTPAEADHLF
KILGVLREQGKTIILITHKLREIMAITDSVSVMRRGEMVATRKTSETSVEELAELMVGRR
VLLRVEKGETTPGDVLLSIRNLTVKDSRGVTMVDDVSLDVRAGEIVGIAGVAGNGQSELL
EAIAGIRKPYSGEIWVDGQKVDRPDPAILRKLGLAHIPEDRHHMGLVLKFEEYENSILGY
HHDERYGKGPFLNPEAIRKDAVEKIEKYDIRPPNPQLKTANFSGGNQQKIVVAREIERDP
KMLIIGQPTRGVDIGAIEFIHRRIIEMRDAGKAILLVSVELDEIRSLSDRIMVMFAGRVV
GEKTAEAEEQTLGLMMAGIAA