Protein Info for Atu0103 in Agrobacterium fabrum C58

Annotation: penicillin-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 764 transmembrane" amino acids 74 to 97 (24 residues), see Phobius details PF00912: Transgly" amino acids 131 to 296 (166 residues), 217.9 bits, see alignment E=6.8e-69 TIGR02074: penicillin-binding protein, 1A family" amino acids 135 to 651 (517 residues), 622.3 bits, see alignment E=4.1e-191 PF00905: Transpeptidase" amino acids 389 to 613 (225 residues), 117.3 bits, see alignment E=7.9e-38

Best Hits

KEGG orthology group: None (inferred from 100% identity to atu:Atu0103)

Predicted SEED Role

"Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-)" in subsystem Peptidoglycan Biosynthesis or Type IV pilus (EC 2.4.1.129, EC 3.4.-.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.4.1.129, 3.4.-.-

Use Curated BLAST to search for 2.4.1.129 or 3.4.-.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CKP7 at UniProt or InterPro

Protein Sequence (764 amino acids)

>Atu0103 penicillin-binding protein (Agrobacterium fabrum C58)
MAGKGKSRERVEPSFGDFHESGDDLRLDASERISGASKQQAKKPRPASGRTKSRKKEKRS
RNSGRGVTGFIRSLFYWCIVLGIWGGIGVAGLVLYYGARMPSASSWSIPERPPNVKIVSV
NGSVLANRGTTGGEALALEDMSPYIPQAVMAIEDRRFYSHFGVDPLGLGRAIVTNVLTGR
AVQGGSTLTQQLAKNLFLSPDRTLERKVQEVLLSFWLEHEFTKDQILAMYLNRVYFGSNA
YGVEAASRRYFNKSARDVNLGEAAMLAGLLKAPSRLSPARDPQAAEERAQVVLQSMRDVG
FITDDEIKTAMSQPPTKAKRFWSGAEHYAADMVLEEVRGLVGEVKQDIVVDTTIDPNLER
DAEKALTHVLQGDGKKQGASQAALVSIDGTGAIRAVVGGADYAQSQFNRAVKAKRQPGSA
FKPFVYVAALESGLTPYTIRNDGPVRIGNWTPENYEKKYRGEVTLATALANSLNTIAAQL
VMEVGPERVTQVAHRMGIESELQNNASIALGTSEVSLMELTASYAPFMNGGYKATPHIVK
RITDADGKVLYENKYDNPPRVLSEEIAATMNGMLSRVITEGTGKAARLQGWQAAGKSGTT
QSFRDALFVGYTSNLTTGVWFGNDDGTSMKKVTGGGLPARAWKDFMTAAHSGLSPSPLFG
LGAGGVPPLGDMQQPAPEAAPSSIGEIISNALGGGTTDTRAYPDAPVSPNQPGMAMPPAN
IPSRDIEPGYQAGNGPVPPADIGGQAPAQSGPKQTTLLDILMGN