Protein Info for Atu0051 in Agrobacterium fabrum C58

Annotation: two component sensor kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 435 transmembrane" amino acids 23 to 43 (21 residues), see Phobius details amino acids 49 to 69 (21 residues), see Phobius details amino acids 81 to 101 (21 residues), see Phobius details amino acids 107 to 122 (16 residues), see Phobius details amino acids 129 to 149 (21 residues), see Phobius details amino acids 161 to 183 (23 residues), see Phobius details PF00512: HisKA" amino acids 214 to 272 (59 residues), 34.3 bits, see alignment E=1.9e-12 PF02518: HATPase_c" amino acids 326 to 426 (101 residues), 67.5 bits, see alignment E=1.4e-22

Best Hits

KEGG orthology group: K15011, two-component system, sensor histidine kinase RegB [EC: 2.7.13.3] (inferred from 100% identity to atu:Atu0051)

Predicted SEED Role

"Sensor histidine kinase PrrB (RegB) (EC 2.7.3.-)" (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7D2A4 at UniProt or InterPro

Protein Sequence (435 amino acids)

>Atu0051 two component sensor kinase (Agrobacterium fabrum C58)
MAGHPIETTRLGRASRRIRLQTIIWLRWLAVAGQTATILFVAFALNFPLPLLACGLLIAA
LALANLFLTARFPSTYRLEPWEATLLLAFDLLQLTALIYITGGLSNPFAPLICVQVIIAF
ASQPLKHSLILLGFAVICSTAIAFSPFPVPWYPDEVLPIQLLLHVGTWVAIIATTSFAAF
YAYRVSHEANQLADALAATELVLEREKHLSQLDGLAAAAAHELGTPLATISVVAKEMERE
LGHDEKYGEDIALLRSQSERCRDILRRLTSLSADNEEHMSRLPLSSLIEEVMAPHREFGI
RLELVEKTGRAEEPVGIRNAGIIYGLGNLIENAVDYAREKVTVTVDHDAQNVAVTIEDDG
PGYAHDVLARIGEPYVTERHNDTRAGGLGLGLFIAKTLLERSGAAVTFENRASSKSGARV
TIVWPRALMDDKRSR