Protein Info for AMB_RS23185 in Magnetospirillum magneticum AMB-1

Annotation: HAMP domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 645 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 138 to 160 (23 residues), see Phobius details PF00672: HAMP" amino acids 162 to 209 (48 residues), 37.5 bits, see alignment 3.7e-13 TIGR00229: PAS domain S-box protein" amino acids 219 to 344 (126 residues), 30.6 bits, see alignment E=1.6e-11 PF08448: PAS_4" amino acids 229 to 339 (111 residues), 25.8 bits, see alignment E=1.6e-09 PF02518: HATPase_c" amino acids 536 to 644 (109 residues), 74.6 bits, see alignment E=1.3e-24

Best Hits

KEGG orthology group: None (inferred from 100% identity to mag:amb1050)

Predicted SEED Role

"Signal transduction histidine kinase HoxJ (hydrogenase regulation)" in subsystem Hydrogenases or Membrane-bound Ni, Fe-hydrogenase

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2W8H1 at UniProt or InterPro

Protein Sequence (645 amino acids)

>AMB_RS23185 HAMP domain-containing protein (Magnetospirillum magneticum AMB-1)
MSIRSKLLIPLLLLAACVLASMHFIAFDTLKKTLVAERISSEQRALSLLALAIAPDVQAS
DLAKIHETMGESKAQHSWWRSLTLTSPAGLRLYPLLQSNTQPGSNLRLTAPVSAAGRRLG
ELSMEVDQETLVAPALSVVYGLEVVVALILILGTMAVVGLQTRMVISPLRRLVEASNLLS
KGQYDVVLPPSSADEVGNLVSAFEIMRSSVANREAALTESEGRFRDLAESASDWFWETDT
DYRLTFVSDRIGAILGVKPSAILGYTYFDVGLSDFDADLARTHADDLANHRPFRDLMFHI
GPVDGKDEKIVRISGMPFYDQDSAFIGYRGIGADVTREARAEERARQAQLELADQHAQLE
RLVEERTEALKQAQIEALQASRMASVGQLAAGIAHEINTPIQYVGDNLAFIQSAAEAVFP
LLSEARALAESWRVGEGDAGKTEEFLQHYDAAGLDFLMEETLPAVTQSLEGVAQVARIVL
SMKEFSHPGTSQKTAVDINRALDSTLVVCRNTWKHVARMETRFDPALPLVNCHPGEMNQV
FLNLIVNAAHAIEESGKPLPGTITAETALCGDWAEIRISDSGTGISDEIAQHIFDPFFTT
KEVGKGTGQGLAICYDVVVNKHGGQIVVGGEPEHGAIFTIRIPVG