Protein Info for AMB_RS22540 in Magnetospirillum magneticum AMB-1

Annotation: alpha-hydroxy-acid oxidizing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01070: FMN_dh
  • amino acids 16 to 377 (362 residues), 401.8 bits, E=1.3e-124

Best Hits

Swiss-Prot: 36% identical to LLDD_PSEFS: L-lactate dehydrogenase (lldD) from Pseudomonas fluorescens (strain SBW25)

KEGG orthology group: K00101, L-lactate dehydrogenase (cytochrome) [EC: 1.1.2.3] (inferred from 100% identity to mag:amb4454)

Predicted SEED Role

"L-lactate dehydrogenase (EC 1.1.2.3)" in subsystem L-rhamnose utilization or Lactate utilization or Respiratory dehydrogenases 1 (EC 1.1.2.3)

MetaCyc Pathways

• methylglyoxal degradation V (1/3 steps found)
• lactate fermentation to acetate, CO₂ and hydrogen (Desulfovibrionales) (4/8 steps found)

KEGG Metabolic Maps

• Pyruvate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.2.3

Sequence Analysis Tools

See Q2VYR7 at UniProt or InterPro

Protein Sequence (384 amino acids)

>AMB_RS22540 alpha-hydroxy-acid oxidizing protein (Magnetospirillum magneticum AMB-1)
MTINHAASIGDLAKLARWRIPGFAFGFLDGGSGEEGGLRRNRERLEAAVLAPKACTGAKP
DTTASLFGRDYALPFGAAPVGMGNLLWPGADLMVARQAARLGFPVVASTVATTALEDIAA
AAEGHAWFQLYVSREERINRDLLARAWAAGIRELVITVDVPVAGDRRRDVRNRFILPFKP
GPRFVAQVAMAPLWALSTLRAGSPGFPNLTRYVGEVDGKTLAGFISSQIKDDLAWDDVRA
LRDLWQGRLLIKGIMTAADARTALDLGADGIWVSNHGGRQLDAAPAAIDSLAAIRAALGK
EAVILMDGSIRSGEDVVRAGATGADFVFCGRAFYYGAAAAGEGGAARAADLLAADVRRTL
TQIGCPSWMGLDEGWLWKESGCRP