Protein Info for AMB_RS18600 in Magnetospirillum magneticum AMB-1

Annotation: leucyl aminopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF02789: Peptidase_M17_N" amino acids 17 to 146 (130 residues), 90.4 bits, see alignment E=8.9e-30 PF00883: Peptidase_M17" amino acids 183 to 488 (306 residues), 424.5 bits, see alignment E=2.6e-131

Best Hits

Swiss-Prot: 56% identical to AMPA_RHOP5: Probable cytosol aminopeptidase (pepA) from Rhodopseudomonas palustris (strain BisA53)

KEGG orthology group: K01255, leucyl aminopeptidase [EC: 3.4.11.1] (inferred from 100% identity to mag:amb3676)

Predicted SEED Role

"Cytosol aminopeptidase PepA (EC 3.4.11.1)" (EC 3.4.11.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.4.11.1

Use Curated BLAST to search for 3.4.11.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2W0Z5 at UniProt or InterPro

Protein Sequence (500 amino acids)

>AMB_RS18600 leucyl aminopeptidase (Magnetospirillum magneticum AMB-1)
MKIAFSKPSLPASGAVAVGILEGKVLTGTAQALDAQAKGGLARAIAASGRFEGKKGQTLL
ILAPAGLELSRVLLVGLGKAKDLDALAAQAFGGTVVGQLQTSGDADVAVALDVIPGSPLS
PAEFAAQAALGARLRSYRFDKYMTKQKKEDKPSLKKLSLLTDAAADAKAAFGALDKVADA
VFLTRDVVSEPANIIHPESLAEKAESLKDLGVEVEVLGEKQMKKLGMGSLLGVGQGSERE
SKLVIMRWSNAAKKDEAPVAFVGKGVTFDSGGISIKPGAGMEDMKWDMAGAGAVIGALAA
LAGRKAKVNAIGVVGLVENMPSGTAQRPGDVVTSMSGQTIEVINTDAEGRLVLADALWYT
QDRFKPKFMVDLATLTGAIIIALGNEYAGLMSSDDKLADRLTAAGKAVDEKLWRLPLGES
YDKQIKSDIADMKNVGGREGGSITAAQFLKRFTNDVAWAHLDIAGVAWSKKDVATCPKGA
TAFGVRLLDRLVADFYEDKK