Protein Info for AMB_RS18195 in Magnetospirillum magneticum AMB-1

Annotation: DUF1487 domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 33 to 491 (459 residues), 511.9 bits, E=7e-158

Best Hits

Swiss-Prot: 42% identical to BETB_AGRFC: NAD/NADP-dependent betaine aldehyde dehydrogenase (betB) from Agrobacterium fabrum (strain C58 / ATCC 33970)

KEGG orthology group: None (inferred from 100% identity to mag:amb3595)

MetaCyc: 39% identical to 4-hydroxymuconic-semialdehyde dehydrogenase (Pseudomonas sp. ENV2030)
4-hydroxymuconic-semialdehyde dehydrogenase. [EC: 1.2.1.61]

Predicted SEED Role

"Aldehyde dehydrogenase (EC 1.2.1.3)" in subsystem Entner-Doudoroff Pathway or Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism or Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate (EC 1.2.1.3)

MetaCyc Pathways

• octane oxidation (4/5 steps found)
• ethanol degradation II (2/3 steps found)
• ethanol degradation III (2/3 steps found)
• ethanol degradation IV (2/3 steps found)
• hypotaurine degradation (2/3 steps found)
• putrescine degradation IV (2/3 steps found)
• ethylene glycol degradation (1/2 steps found)
• putrescine degradation I (1/2 steps found)
• putrescine degradation V (1/2 steps found)
• L-tryptophan degradation X (mammalian, via tryptamine) (2/4 steps found)
• fatty acid α-oxidation I (plants) (2/4 steps found)
• phytol degradation (2/4 steps found)
• histamine degradation (1/3 steps found)
• 3-methyl-branched fatty acid α-oxidation (3/6 steps found)
• Entner-Doudoroff pathway II (non-phosphorylative) (5/9 steps found)
• mitochondrial NADPH production (yeast) (2/5 steps found)
• D-arabinose degradation II (1/4 steps found)
• putrescine degradation III (1/4 steps found)
• 4-hydroxyacetophenone degradation (1/5 steps found)
• 4-nitrophenol degradation I (1/5 steps found)
• dopamine degradation (1/5 steps found)
• superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (3/8 steps found)
• superpathway of ornithine degradation (3/8 steps found)
• ceramide degradation by α-oxidation (2/7 steps found)
• serotonin degradation (2/7 steps found)
• sphingosine and sphingosine-1-phosphate metabolism (4/10 steps found)
• alkane oxidation (1/6 steps found)
• limonene degradation IV (anaerobic) (1/7 steps found)
• superpathway of glycol metabolism and degradation (1/7 steps found)
• aromatic biogenic amine degradation (bacteria) (1/8 steps found)
• superpathway of L-arginine and L-ornithine degradation (4/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (2/11 steps found)
• noradrenaline and adrenaline degradation (2/13 steps found)
• ceramide and sphingolipid recycling and degradation (yeast) (4/16 steps found)
• superpathway of pentose and pentitol degradation (4/42 steps found)

KEGG Metabolic Maps

• 1,2-Dichloroethane degradation
• 3-Chloroacrylic acid degradation
• Arginine and proline metabolism
• Ascorbate and aldarate metabolism
• Butanoate metabolism
• Fatty acid metabolism
• Glycerolipid metabolism
• Glycolysis / Gluconeogenesis
• Histidine metabolism
• Limonene and pinene degradation
• Lysine degradation
• Propanoate metabolism
• Pyruvate metabolism
• Tryptophan metabolism
• Urea cycle and metabolism of amino groups
• Valine, leucine and isoleucine degradation
• beta-Alanine metabolism
• gamma-Hexachlorocyclohexane degradation

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.3

Use Curated BLAST to search for 1.2.1.3 or 1.2.1.61

Sequence Analysis Tools

See Q2W176 at UniProt or InterPro

Protein Sequence (496 amino acids)

>AMB_RS18195 DUF1487 domain-containing protein (Magnetospirillum magneticum AMB-1)
MTLTPELDPFKLAKALSGKHLIGGKLVPAGCGEVFEVDNPATGEIIGTAAFGTKEDVDIA
VISAKAAQKDWAKQSARARGKLVAECGRVLSAHVEELGRLVALETGKALRTESRVEAGVL
ADMFTFFGGLGSELKGETIPFNPDMLTVTVREPVGVVGCIIPWNVPLLLMAMKAAAALVA
GNSVVVKSAEEAPLTVLRVAEIMNTVLPPGLFNMLSGFGPECGAPLVEHPDVKKVTFTGS
VETGRIVYKAAAEKLIPVTLELGGKSPMIVCADADMDQAVAGALAGMRFTRQGQSCTASS
RLFVHESIHDEFVAKVKAKVDAMVMGDPLDEKTDIGTIVSDGQLERVRSYIKIGEETKGA
TKHVCSALPTDPKLAKGRFVQPVIFTGMKNSDRLCQEEIFGPVCAVIKWSDYEDVLAQAN
DSEYGLAASIWTRDFKLAMDATKRLEAGFVQVNQNLVVQPGLSYGGVKTSGIGKEASLES
MLEHFTHKKTIIFNMK