Protein Info for AMB_RS18140 in Magnetospirillum magneticum AMB-1

Annotation: malonyl-CoA synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00501: AMP-binding
  • amino acids 25 to 364 (340 residues), 286.6 bits, E=2.8e-89
• PF13193: AMP-binding_C
  • amino acids 415 to 490 (76 residues), 52 bits, E=1.1e-17

Best Hits

KEGG orthology group: None (inferred from 100% identity to mag:amb3584)

Predicted SEED Role

"Acetoacetyl-CoA synthetase [leucine] (EC 6.2.1.16)" in subsystem HMG CoA Synthesis or Leucine Degradation and HMG-CoA Metabolism (EC 6.2.1.16)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (48/53 steps found)
• superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
• palmitate biosynthesis II (type II fatty acid synthase) (29/31 steps found)
• palmitate biosynthesis III (21/29 steps found)
• sphingosine and sphingosine-1-phosphate metabolism (4/10 steps found)
• stearate biosynthesis I (animals) (1/6 steps found)
• 2-deoxy-D-ribose degradation II (2/8 steps found)
• ceramide and sphingolipid recycling and degradation (yeast) (4/16 steps found)

KEGG Metabolic Maps

• Butanoate metabolism

Isozymes

Compare fitness of predicted isozymes for: 6.2.1.16

Use Curated BLAST to search for 6.2.1.16

Sequence Analysis Tools

See Q2W187 at UniProt or InterPro

Protein Sequence (508 amino acids)

>AMB_RS18140 malonyl-CoA synthase (Magnetospirillum magneticum AMB-1)
MTDNLFELFRSRFPADRSRPFIEVPGGITVSYGDMEAMSARYAHALVAAGVKPGDRVAVQ
VDKSAEAVVLYLACLRSGAVLLPLNTAYQAGELEYFLFDAAPSAVVCQPSRLAELEGLAV
AAGIGTCVMTLGSHGDGTLPERAKGLSETFATVPRGGDDMAAILYSSGTTGRPKGAMMSH
TNLGSNAQTLHDLWGFRPDDVLLHCLPIFHTHGLFVAINCVLLNGSPMIFCPKFDAEQAI
GLLKRATVFMGVPTFYTRFLTSPNLTPEACSHMRLFISGSAPLLEETFNAFKDKTGFTIL
ERYGMTEGGMFTSNPLVGDRRAGTVGFPLPDVQLRITGEEGQVLPQGEVGIIEVKGPNIF
KGYWNMPEKTKSDFTEDGFFKSGDVGVVDARGYVSIVGRAKDLIISGGYNVYPKEVEDFI
DRLAGVVESAVVGMPHPDFGEAGLAIVVAEKGASLTAEGVIDSLKGRLANYKVPKLAVVV
TELPRNAMGKVQKNVLRDSYAAMWKANL