Protein Info for AMB_RS17370 in Magnetospirillum magneticum AMB-1

Annotation: acriflavine resistance protein B

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1022 signal peptide" amino acids 1 to 37 (37 residues), see Phobius details transmembrane" amino acids 335 to 353 (19 residues), see Phobius details amino acids 360 to 382 (23 residues), see Phobius details amino acids 389 to 411 (23 residues), see Phobius details amino acids 431 to 455 (25 residues), see Phobius details amino acids 463 to 489 (27 residues), see Phobius details amino acids 513 to 518 (6 residues), see Phobius details amino acids 523 to 542 (20 residues), see Phobius details amino acids 853 to 870 (18 residues), see Phobius details amino acids 890 to 915 (26 residues), see Phobius details amino acids 950 to 969 (20 residues), see Phobius details amino acids 981 to 1006 (26 residues), see Phobius details PF00873: ACR_tran" amino acids 6 to 1007 (1002 residues), 1066.9 bits, see alignment E=0

Best Hits

Swiss-Prot: 55% identical to MDTB_EDWTE: Multidrug resistance protein MdtB (mdtB) from Edwardsiella tarda (strain EIB202)

KEGG orthology group: K07788, RND superfamily, multidrug transport protein MdtB (inferred from 65% identity to azl:AZL_d04470)

MetaCyc: 54% identical to multidrug efflux pump RND permease subunit MdtB (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-352; TRANS-RXN-353; TRANS-RXN-92

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2W1N7 at UniProt or InterPro

Protein Sequence (1022 amino acids)

>AMB_RS17370 acriflavine resistance protein B (Magnetospirillum magneticum AMB-1)
MNVSAPFIRRPVATWLLAFAVVLAGILGFRLLPVSALPQVDFPTIQVTTQLPGASAETIA
TLITTPLERQFGLIPGLAVMTSTSSQGTSALTLQFDLSKSIDVASEEVQAAIDAARGVLP
TQLPYPPVYSKVNPADPPIMTLALTSDSLPITRLNDVADTLLAQKLSQIGGVGRVLIEGG
QRPAVRVRMDPARLAAYGLSLEDVRSALSKANVDMPKGSFDGVAQALSIGANDQISDPLA
YPAQVVAWKNGAPVRVSDLGDVVEGVENSRVAGWFDGKPAVILNIQRQPGANIVATVDRL
QAKLPELTRVVPTGVKVSVLADRTETIRASVADVEFTLVLTIILVIGVIWAFLRSVRATL
IPAVALPLSLIGTFGVMALAGFSLDNLSLMALTISAGFVVDDAIVMIENIVRYIEKGMKP
LDAALAGSKEIGFTIVSLTVSLVAVFIPLLFMTGIVGRLFREFALTLAVAVVVSAVVSLT
LTPMMCAHLLKGGHEEAKSGRFFLALSRAYARSLDWVLGHQAATLWVAFATLALTIGLYV
FMPKGFLPTQDTGLIVATTDARADVSFSTMMDMQRRVSELARTDADVTAVASFIGAGPIN
PTANTGQMTIVLKPRKQRSASAEQIIARLAEKVSPVAGMEVHFRPAQDIQISHRTSRTQY
QYTLTDIDAVELAQWVPLVVERLRASPLLTDVATDSQEGGLQADIRIDRDKAARLGVLPQ
AIDDTLYDAFGQRQISTIYSQVNQYKVVLEVTPEYQGGPEALGALYVRSSSGALVPLSAV
ASVTRARVPLLITHQGQFPAVTISFNLASGASLGAATAAIDALQHEMGMPETITGEYSGD
AAEFRRALDSQPWLIVAAMVVIYIVLGVLYESTIHPVTIMSTLPSAGIGALLALLVTGHD
LSLVGLIGIVLLMGIVKKNAIMMIDFAIEAERHEGLNPRDAIVKASLLRFRPIMMTTMAA
LLGAIPLAIDAGTGSELRRPLGISIVGGLVLSQLITLYTTPVIYLAFERLKRRFVPAAAP
AE