Protein Info for AMB_RS17220 in Magnetospirillum magneticum AMB-1

Annotation: GGDEF domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 424 PF00989: PAS" amino acids 12 to 103 (92 residues), 33.8 bits, see alignment E=8.9e-12 amino acids 131 to 237 (107 residues), 43.8 bits, see alignment E=6.9e-15 TIGR00229: PAS domain S-box protein" amino acids 13 to 125 (113 residues), 46.5 bits, see alignment E=3.9e-16 amino acids 131 to 246 (116 residues), 67.4 bits, see alignment E=1.3e-22 PF13426: PAS_9" amino acids 24 to 117 (94 residues), 41.4 bits, see alignment E=4.4e-14 amino acids 137 to 239 (103 residues), 54.7 bits, see alignment E=3.3e-18 PF08448: PAS_4" amino acids 133 to 242 (110 residues), 40.2 bits, see alignment E=1.1e-13 PF08447: PAS_3" amino acids 150 to 233 (84 residues), 27.6 bits, see alignment E=8.7e-10 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 249 to 409 (161 residues), 142.5 bits, see alignment E=1e-45 PF00990: GGDEF" amino acids 251 to 408 (158 residues), 166.2 bits, see alignment E=1.7e-52

Best Hits

KEGG orthology group: None (inferred from 100% identity to mag:amb3405)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2W1R6 at UniProt or InterPro

Protein Sequence (424 amino acids)

>AMB_RS17220 GGDEF domain-containing protein (Magnetospirillum magneticum AMB-1)
MTELDPIGLAGVLEDSPIGVSISRRRDGVIVFANHTFCDLIGVPRVTVLGSKARDYYVDD
HQRATVIKHMKRHGSVDHAEVQFRRSDGAPFWTLLTIRESLFGTEPVNLAWVYDITERKT
SEERLQLAAKVVETANEGIMITGPDGTIEAVNTAFTRITGFSLDEAIGKKPNILKSGRHE
NDFYRDMWRAILETGQWQGEVWNRRRTGEVFIEWLSIATVRDAFGEVSHMLGIFSDITAR
KEDEEQVWRQANFDALTGLPNRSLFLDRLGQAVKAAKRDKTRFALLFIDLDGFKKVNDTF
GHAVGDLLLQEAAARLLLSVRSSDTVARLSGDEFTVILHDVEGKDEIGNVAAKVVSRLAE
PFELDGHDANVQASVGIAIFPDDADDAAMLIRLADRAMYTVKGAGKNNFGFHEMPERLVY
PLYA