Protein Info for AMB_RS13770 in Magnetospirillum magneticum AMB-1

Annotation: nicotinate phosphoribosyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 468 PF18127: NAMPT_N" amino acids 8 to 103 (96 residues), 84 bits, see alignment E=7.4e-28 PF04095: NAPRTase" amino acids 177 to 448 (272 residues), 197.1 bits, see alignment E=3.9e-62

Best Hits

KEGG orthology group: K00763, nicotinate phosphoribosyltransferase [EC: 2.4.2.11] (inferred from 100% identity to mag:amb2738)

Predicted SEED Role

"Nicotinamide phosphoribosyltransferase (EC 2.4.2.12)" in subsystem NAD and NADP cofactor biosynthesis global or NAD regulation (EC 2.4.2.12)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.11 or 2.4.2.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2W3N3 at UniProt or InterPro

Protein Sequence (468 amino acids)

>AMB_RS13770 nicotinate phosphoribosyltransferase (Magnetospirillum magneticum AMB-1)
MRGGLNPILAVDSYKASHKWQYPPGTEYVSSYVEARADNSGLDLPGTLVFGLQPLLRTLA
AHPVGEADIVRAARLFAAHGVPFHEEGWRHILSRHGGRLPVEIRAVAEGTLVPFSNVVAQ
VVNTDPQAFWLTSYLETMLQRALWYPSTVATVSWAVKRILREFWLLTSDDAEGSLDFKLH
DFGARGASSGESAALGGLAHLVNFKGTDTVEALLAAEEHYAEPMAGYSIPAAEHSTITSW
GRQGEVDAYANMLEQFGGPGRLVAVVSDSYDVFHAVENLWGRELRAQVLDMGGTLVIRPD
SGDPVDVVSQVLRLAAAAFGSTRNSKGFRILNPAVRVIQGDGVNPKSIRAILARMVEDGF
AIDNIAFGMGGALLQKVDRDTFSWAMKASAVRVAGQWRDVYKEPVTDGGKGSKRGRLALV
RDPAEGLRTVRLEDCPAGEDLLRPVFRDGTLLVEDSLAQVRHRAYFGR