Protein Info for AMB_RS12610 in Magnetospirillum magneticum AMB-1

Annotation: bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase PutA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1039 transmembrane" amino acids 692 to 710 (19 residues), see Phobius details PF14850: Pro_dh-DNA_bdg" amino acids 66 to 175 (110 residues), 142 bits, see alignment E=1.6e-45 PF01619: Pro_dh" amino acids 184 to 475 (292 residues), 341.3 bits, see alignment E=7.5e-106 TIGR01238: delta-1-pyrroline-5-carboxylate dehydrogenase" amino acids 508 to 1010 (503 residues), 598.4 bits, see alignment E=4.9e-184 PF00171: Aldedh" amino acids 556 to 1009 (454 residues), 358.7 bits, see alignment E=6.2e-111

Best Hits

KEGG orthology group: K13821, proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC: 1.5.1.12 1.5.99.8] (inferred from 100% identity to mag:amb2507)

Predicted SEED Role

"Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.2.1.88)" in subsystem Proline, 4-hydroxyproline uptake and utilization or Respiratory dehydrogenases 1 (EC 1.2.1.88, EC 1.5.99.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.88 or 1.5.1.12 or 1.5.99.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2W4B4 at UniProt or InterPro

Protein Sequence (1039 amino acids)

>AMB_RS12610 bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase PutA (Magnetospirillum magneticum AMB-1)
MIFTAPLPAPDPERQAIHRAAGTSEADLVSGLSAGIPLEDEARRRIVNRAVNLVDGARRN
RRTLGLDGLLNEYRLSTREGVVLMCLAEALLRIPDDHTVDLLIKDKIASADWDGHLGHSP
SVFVNASTWALVLGDRLLHLEEDGRAVLGRMAGRLGEAVVRRALRHAMGLMGRQFVLGRT
IAEALDNARAWEARGYRHSFDMLGEAARCEQAAQDYLRAYAGAIEALGRHAKGAGPIAGP
GLSVKLSALHPRFEMAQRQRVLGELVPRLRDLCHRARDAGIGLTIDAEEADRLDISLDVM
EAALADPALDGWDGFGMAVQAYQKRARPVIAWAGALAARRQQRLMIRLVKGAYWDGEVKR
AQERGLGGFPVFTTKEATDVSYLACAADLLARPDLFYPQFATHNAHTAAAVMEMTGGAGD
WEFQRLHGMGEALYAQLVPEFPCRTYAPVGSHQELLPYLVRRLLENGANSSFVSRLADEE
IPAHVVAADPLAALGRITPQLVAEPSALFGPSRRNSGGLDLSSPAVLAQLDLALAAVATP
ERSAPIVDGRERENQAAKPVLDPADHRRVVGEVVDASPADVEAALASARAAFPAWDDLGG
EARASILERAADRLEADRARFMALAIREAGKTIPDALSEVREAVDFLRFYAAEARARFSQ
PVRLPGPVGESNELMLGGRGVFACISPWNFPLAIFVGQVAAALAAGNAVVAKPAPQTPLM
AAAAVRLLHQAGVPPQALHLVPGGPAIGEALTVNPLVDAIAFTGSTATARHINRLRAAMD
GPLAPLIAETGGLNAMIVDSSALPEQVVADCLESAFRSAGQRCSALRVAFIQREAWTRIQ
PLLAGAMAELSLGDPALLSTDVGPVIDEASRRRLLAHGGRLRHAGRMIGQSACPPDCRVG
TFFAPMAHQLDNLDLLQSEVFGPILHVIPWEAGRLEQVLDCVAATSYGLTLGIHSRIDAT
IAQVIARARIGNIYVNRTMIGAVVGSQPFGGLGLSGTGAKAGGPNTLIRYGVERCLSVNT
AAAGGDVALMAGPQRHGTK