Protein Info for AMB_RS11225 in Magnetospirillum magneticum AMB-1

Annotation: TlpA family protein disulfide reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 193 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF08534: Redoxin" amino acids 68 to 167 (100 residues), 51 bits, see alignment E=2.9e-17 PF00085: Thioredoxin" amino acids 68 to 118 (51 residues), 27.5 bits, see alignment E=5.4e-10 PF00578: AhpC-TSA" amino acids 69 to 158 (90 residues), 53.7 bits, see alignment E=4.2e-18 PF13905: Thioredoxin_8" amino acids 69 to 159 (91 residues), 28.9 bits, see alignment E=2.3e-10

Best Hits

KEGG orthology group: None (inferred from 100% identity to mag:amb2218)

Predicted SEED Role

"Thiol:disulfide oxidoreductase TlpA" in subsystem Biogenesis of c-type cytochromes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2W553 at UniProt or InterPro

Protein Sequence (193 amino acids)

>AMB_RS11225 TlpA family protein disulfide reductase (Magnetospirillum magneticum AMB-1)
MSDRILILVALSLIIAMVAGTAIQIRKPQPTPILVKESMRRPDYAIPLDNPMTTDMAGVT
VPFLSRITKPTVVNFWATWCIPCVRELPLFAKFKPIAEAAGIQVLTVNVDKEGAPVAKKF
LEERGIADMPMILDPDGSVSKVLKVRGMPTALLVNAKGEETARMEGEADWAGPGVIDVVR
ELLALPSHPVMAK