Protein Info for AMB_RS10965 in Magnetospirillum magneticum AMB-1

Annotation: cytochrome c oxidase subunit II

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 293 signal peptide" amino acids 1 to 37 (37 residues), see Phobius details transmembrane" amino acids 60 to 83 (24 residues), see Phobius details amino acids 104 to 127 (24 residues), see Phobius details PF02790: COX2_TM" amino acids 39 to 125 (87 residues), 80.2 bits, see alignment E=1e-26 TIGR02866: cytochrome c oxidase, subunit II" amino acids 52 to 264 (213 residues), 203.2 bits, see alignment E=1.6e-64 PF00116: COX2" amino acids 137 to 255 (119 residues), 171.7 bits, see alignment E=5.3e-55

Best Hits

Swiss-Prot: 49% identical to COX2_RICBR: Probable cytochrome c oxidase subunit 2 (ctaC) from Rickettsia bellii (strain RML369-C)

KEGG orthology group: K02275, cytochrome c oxidase subunit II [EC: 1.9.3.1] (inferred from 100% identity to mag:amb2170)

Predicted SEED Role

"Cytochrome c oxidase polypeptide II (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2W5A1 at UniProt or InterPro

Protein Sequence (293 amino acids)

>AMB_RS10965 cytochrome c oxidase subunit II (Magnetospirillum magneticum AMB-1)
MTADEETAGRDIRMNRSTQALMAAAVLIGLAPVAMAGEPQPWALSFQHGVSPTMERITSL
ATFINGVIVVITLLVSGLLLYACTRFRADRNPKPATWSHNTPLEVVWTAIPAVILLLIAI
PSFRLLYFMDRVHDADMTLKIVGHQWYWTYEYPDHDFKFDSNMVQAEDLKPGQPRLLTAD
NTLVVPAGVPIRLQMTADDVIHSWSVPAFGIKTDAVPGRLNETWVQVNEPGTYYGQCSQL
CGVNHGFMPVHVKAVPKEEFLAWVAQAKKTYAHLDGSRPETAVALAETGGKSP