Protein Info for AMB_RS09655 in Magnetospirillum magneticum AMB-1

Annotation: sensor histidine kinase KdpD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 895 transmembrane" amino acids 397 to 420 (24 residues), see Phobius details amino acids 427 to 459 (33 residues), see Phobius details amino acids 474 to 493 (20 residues), see Phobius details PF02702: KdpD" amino acids 21 to 229 (209 residues), 318.6 bits, see alignment E=5.9e-99 PF00582: Usp" amino acids 250 to 364 (115 residues), 29.3 bits, see alignment E=4e-10 PF13493: DUF4118" amino acids 400 to 504 (105 residues), 102.7 bits, see alignment E=3.2e-33 PF13492: GAF_3" amino acids 525 to 643 (119 residues), 56.1 bits, see alignment E=1.9e-18 PF00512: HisKA" amino acids 663 to 730 (68 residues), 52.8 bits, see alignment 1.1e-17 PF02518: HATPase_c" amino acids 775 to 885 (111 residues), 97.7 bits, see alignment E=2e-31

Best Hits

KEGG orthology group: K07646, two-component system, OmpR family, sensor histidine kinase KdpD [EC: 2.7.13.3] (inferred from 100% identity to mag:amb1912)

Predicted SEED Role

"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2W609 at UniProt or InterPro

Protein Sequence (895 amino acids)

>AMB_RS09655 sensor histidine kinase KdpD (Magnetospirillum magneticum AMB-1)
MSEPQRPSPDALLAQARREGRGRLKIFLGAAPGVGKTYAMLCAAHERLKDGVDVVAGVVE
THGRKETEALVKGLDVLPARLVEYRGREFREMDLDALISRRPAIALVDELAHANVPGSRH
LKRWQDVEEVLAAGINVYATLNIQHLESLNDVVERISGVKVRETLPDGVLAGADEIELID
LPPADLIKRLNEGKVYVPEQARRAVGHFFSPGNLTALREMALRHAAERVDAQMVDYMRSN
AIAGPWPARERIMVCIDERADSDRLVRVAKRAADRRGAAWVAVTVETSHTLTLPEADKDR
VAAAMRLAAQLGGETAHLQGDDVVAVVLACAAERNATQIVVGRPRRLRLLDHFAATVTDR
LVERGGAFNVLVVGDDSEDARKVPKPTAVQPEPQDWPGLALALAAAGAATGLGFAIDLWL
SVASISVAYLLAVMVVAMWIGLRPGILASVASFLAFNFFFTEPRFTFAVSDVQNLLTLAF
FLIAAFIVSGMASRLRAQVQASRESARRTVNLYEFGRKVTGAATQDDVLWAVVHHVADTI
RGRSLVLMPVEGRLSVMAGYPPEDHLDDKSAAAAEWAWSHGKPAGRGSATLPAALWLFLP
LRTGRSAVGVLGVQMSEDADLPSPAQMRLLETLADQAAVAIERTTLVSDIEAARVATERE
RLRSALLSSLSHDLRTPLVSIMGAASSLISYDDILGPADRRDLAQTVQDEAERLNRFVQN
LLDMTRLGSGTLKPRIDWADLSDIVGGAVERAARLTRSHAVKVDIDPDMPLLCVDAVLLG
QVFFNLLDNACKYSPPGTGIKVWARRAADHISIEVADQGPGIPEADREKVFDMFYRVGLT
DSQPAGTGLGLAICRGIVEAHGGTIRAEAGLHGSGTAIIIRLPLPPSPDVAGEEA