Protein Info for AMB_RS09145 in Magnetospirillum magneticum AMB-1

Annotation: copper-translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 735 transmembrane" amino acids 107 to 124 (18 residues), see Phobius details amino acids 136 to 154 (19 residues), see Phobius details amino acids 168 to 188 (21 residues), see Phobius details amino acids 195 to 215 (21 residues), see Phobius details amino acids 352 to 371 (20 residues), see Phobius details amino acids 377 to 398 (22 residues), see Phobius details amino acids 687 to 704 (18 residues), see Phobius details amino acids 710 to 729 (20 residues), see Phobius details PF00403: HMA" amino acids 20 to 78 (59 residues), 49.4 bits, see alignment 9.6e-17 TIGR01511: copper-translocating P-type ATPase" amino acids 149 to 730 (582 residues), 588.5 bits, see alignment E=3.1e-180 TIGR01525: heavy metal translocating P-type ATPase" amino acids 168 to 729 (562 residues), 633.1 bits, see alignment E=1e-193 TIGR01494: HAD ATPase, P-type, family IC" amino acids 205 to 711 (507 residues), 308.3 bits, see alignment E=1.5e-95 PF00122: E1-E2_ATPase" amino acids 233 to 412 (180 residues), 194.8 bits, see alignment E=1.9e-61 PF00702: Hydrolase" amino acids 429 to 641 (213 residues), 130.3 bits, see alignment E=2.5e-41

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 100% identity to mag:amb1807)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2W6B4 at UniProt or InterPro

Protein Sequence (735 amino acids)

>AMB_RS09145 copper-translocating P-type ATPase (Magnetospirillum magneticum AMB-1)
MGHESDVEDTVMTSQSLSLPVKGMTCAACSTRLERVLGKVDGVEQALVSLAAERADIRFD
GERARPEDLVSAIVKAGFQADLAQSGDEDLDREEAEHAEESARHLRLLMLSALLTLPLIG
QMVLDMAGLHIMIPPLIQLALAAPVQFWIGARFYTGAWASLKGGAGNMDVLVVLGTTAAF
GLSAWHVAAGDAHHGNLYFEGASVVITLVLLGKLLEGRAKRSAAGAIRALMRLKPDTARV
ERDGLVIEVPAALVAVGEVVLVRPGERAPVDGTVVDGESQMDESLITGESLPVPRGPGDE
VVAGAVNGEGLLRVEATRVGAQSTISRIIRMVQGAQAAKAPVQKLVDRISNVFVPVVTVI
AALSFLGWWLIGGNLQVAFVAAVSVLVIACPCALGLATPTGIMVGTGLAARHGILIKDAE
ALELAHKVQVMVFDKTGTLTEGHPAVAAITAADGNGPELLRLAASAQQGSEHPLARALLS
AATGGLAPLGSFRSLPGRGLEAEVEGSSLLIGSRRLMTERSIDPGTLADAAEAEEAQGRT
LMWVAEGARMLGFIAVADPIKASAADAVARLRRLGIETVMLTGDNARAAQAVARAAGVDR
VLAEVLPEDKEAEIRRIKESGKVVAMVGDGINDAPALAAAHIGIAMGTGTDVAMQAAGIT
LVKGDPSRLPEAIAISRATTSKIRQNLFWAFAYNVVAIPAAALGLLTPVIAGAAMAMSSV
SVVSNSLLLRRWRMT