Protein Info for AMB_RS08385 in Magnetospirillum magneticum AMB-1

Annotation: sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 606 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details transmembrane" amino acids 302 to 320 (19 residues), see Phobius details PF02743: dCache_1" amino acids 51 to 229 (179 residues), 52.1 bits, see alignment E=9.7e-18 PF00512: HisKA" amino acids 378 to 442 (65 residues), 30.4 bits, see alignment E=4.8e-11 PF02518: HATPase_c" amino acids 486 to 594 (109 residues), 82.1 bits, see alignment E=6.3e-27

Best Hits

KEGG orthology group: K10125, two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC: 2.7.13.3] (inferred from 100% identity to mag:amb1657)

Predicted SEED Role

No annotation

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2W6R4 at UniProt or InterPro

Protein Sequence (606 amino acids)

>AMB_RS08385 sensor histidine kinase (Magnetospirillum magneticum AMB-1)
MTRPAAPPSARPSHPVAPLLLLAALLGGLVVAWVYQRARIEALDGALVMGQQRLGLYAST
IRAALDRFSYLPATMALDREVIEVLGGHPSQAAALSAKLETINAGARSASLYVMDRRGVT
VAASNWRTETSYVGNDYSFRPYFTQVMTTGTGRFFGIGVTTKLPGYFLASAVRTASGEII
GSVVVKIDLETLEEDWGGGDGAVMVTDEDGMVILTSRPLWKYAVDGPVTTELRRKLDATQ
RYGAVPLRPLERQALLQLGETARLEQVGESAFVAQSQALDEEGWAIHYLADWEVMESNVR
STAALAGLGWVAFILLLLYLRQRRLVLKAKLDAKETLERLVAQRTEALSAEIVERQRTER
HLRETQDELIHAGKMAALGQMSTAIAHELNQPLAAIQTFVASSRIFVERGDAETAGANLT
MIDDLCRRMADIIRHLRVFARKSPVASQVMDPAASVSRAVALLAVRLRQADVDLVWAPPQ
GLMVAGDPGRLDQVFVNLLANAVDAVAQSPARRIQVDAMAVGEDVVITVADSGPGLTSDV
ADRVFEPFFTTKDVGEGLGLGLSLSYGIIRDMGGSIRVENRSGGGAVFLISLPAVGCEGL
HVTHGK