Protein Info for AMB_RS06420 in Magnetospirillum magneticum AMB-1

Annotation: dihydroorotase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 443 TIGR00857: dihydroorotase, multifunctional complex type" amino acids 21 to 426 (406 residues), 324.3 bits, see alignment E=6.2e-101 PF01979: Amidohydro_1" amino acids 53 to 422 (370 residues), 90.2 bits, see alignment E=1.7e-29 PF07969: Amidohydro_3" amino acids 342 to 422 (81 residues), 35.1 bits, see alignment E=1.1e-12

Best Hits

KEGG orthology group: K01465, dihydroorotase [EC: 3.5.2.3] (inferred from 100% identity to mag:amb1265)

Predicted SEED Role

"Dihydroorotase (EC 3.5.2.3)" in subsystem De Novo Pyrimidine Synthesis (EC 3.5.2.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.5.2.3

Use Curated BLAST to search for 3.5.2.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2W7V6 at UniProt or InterPro

Protein Sequence (443 amino acids)

>AMB_RS06420 dihydroorotase (Magnetospirillum magneticum AMB-1)
MAQSFDLILRNGMVVTPNGTGRADIAVSDGRIRALGSLLDASAADEVDLRGLTVLPGIID
TQVHFREPGLEHKEDLESGTRAAAQGGVVAIFEMPNTKPSTTTADAIRDKLDRAQGRAWV
DHAFFIGAASDNIDHLAEWERIPGCAGIKVFMGSSTGNLLVADDETLGRVLAQGFRRIAV
HCEDEGRLIERKHVAEDGAHPRVHHQWRDVETALMASRRLVALAEKAGRRVHVLHVTTAE
EMEFLAGHKDVATVETTPQHLTLAAPECYERLGTYAQMNPPIRGTRHRDALWKAIADGVV
DVLGSDHAPHTREEKDKPYPQSPSGMTGVQTLVPLMLDHVNHGRLSLERLVDLTSAGPAR
IYNIAGKGRIAVGYDADFTVVDMKAERTITNNWIESRCGWTPFDGQKVTGWPVATIVRGR
TVMRDGQLLGQASGEPVRFQETL