Protein Info for AMB_RS06335 in Magnetospirillum magneticum AMB-1

Annotation: CusA/CzcA family heavy metal efflux RND transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1033 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details transmembrane" amino acids 339 to 357 (19 residues), see Phobius details amino acids 363 to 383 (21 residues), see Phobius details amino acids 390 to 407 (18 residues), see Phobius details amino acids 444 to 462 (19 residues), see Phobius details amino acids 473 to 499 (27 residues), see Phobius details amino acids 533 to 553 (21 residues), see Phobius details amino acids 859 to 877 (19 residues), see Phobius details amino acids 884 to 906 (23 residues), see Phobius details amino acids 911 to 931 (21 residues), see Phobius details amino acids 961 to 982 (22 residues), see Phobius details amino acids 993 to 1019 (27 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1022 (1022 residues), 795.5 bits, see alignment E=3.8e-243 PF00873: ACR_tran" amino acids 5 to 1019 (1015 residues), 844 bits, see alignment E=1.6e-257

Best Hits

KEGG orthology group: None (inferred from 100% identity to mag:amb1248)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2W7X3 at UniProt or InterPro

Protein Sequence (1033 amino acids)

>AMB_RS06335 CusA/CzcA family heavy metal efflux RND transporter (Magnetospirillum magneticum AMB-1)
MFDSIIALSLRHRLFVLAAALALTVYGSLVLARLPIDIFPDLNRPTVTIMTEALGLAPEE
SESLVTCHIETAMNGAPGVVRVRSNSGVGLSIVFVEFDWGTDIYRNRQLVAERLSSARDL
LPAGINPVMGPVSSIMGEIMLVGVRSKAGATSPMELRSLADWSLRPRLLSIPGIAQVIPM
GGEVRQIQVLVSPSRMSALGLGYADVEKALAGFARNTTGGFLEQRSAEFLIRNMGQTTDL
NDLRNTVVAWRNNAPVTVDQVAEVRNGAGIRRGDAAIDGQPAVILAVSKQPGADTVTLTR
KVEAALAEIGRTLPADIEADRVLFRQADFISRAVANVAEALRDGAVLVAIVLFAFLMNMR
TTVISLTAIPLSMVVAALVFHAMNLSINTMTLGGLAVAIGELVDDAVVDVENILRRLREN
AATAQPRPVLEVVRSASSEVRNSIVYATMVVVLAFLPLFALSGIEGRLFAPLGIAYVVSI
LASLAVSLTVTPALSLLLLPRARVMGHGDSALVRRLKAWDRILLERSFANPKAVILPALA
LMILAAASVPFLGRTFLPSFNEGTVTVTVVLPPGTSLSESNRIGTIAETLIRQVPEAAST
GRRTGRAELDEHAEGVHYSEIDVDLHPSQRPRDAILGDLRARLAQIPGININIGQPISHR
LDHLLSGVRAEIAVKIFGDDLDTLRSLAAEARTRMQGVRGIADLQVEKLVLIPQVQIRLD
RAEARKYGLGLGQLTETLEAALQGKVVSQVRDGERTTNLVLRLAEDWRAQTSDFRQILVD
TPAGKVPLSLVAEVVETQGPNLINRDNLRRRVVVFANSQGRDLGAIMEELQAELGGMTLP
PGYAIAYEGQFQSRQEATRLIGLLALVSLGAIFALLHAHFRSGLLALVIMANIPMALVGS
VGALWLSGLPLSVAGMVGFVTLAGIASRNGIMKITHYLHLMRHEGEDFGPAMILRGSLER
LTPVLMTALVAALALLPLVLAGGEPGKEILHPVAVVIFGGLMSSTLLDTLVTPAVVLLIG
RKALTNLATEARP